Results 41 to 50 of about 780 (142)

Municipios, autonomía y coordinación

Revista Eurolatinoamericana de Derecho Administrativo, 2014
El tema desarrollado en el presente texto es la cuestión de la autonomía de los Municipios en la Constitución Nacional Argentina, y la forma como el Derecho argentino trata de la problemática de las “áreas metropolitanas” en las ciudades pequeñas y ...
Silvina Claudia Capdevila
doaj   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Consumos informativos y dimensión local en áreas metropolitanas

InMediaciones de la Comunicación
Este artículo examina de qué modo la cuestión local interviene en las prácticas de consumo informativo mediatizado en grandes áreas urbanas. A partir de un estudio empírico en la Zona Norte del Conurbano Bonaerense (Argentina), este trabajo se pregunta ...
Mariano Dagatti, Nadia Koziner, María Celeste Gómez Wagner   +2 more
doaj   +1 more source

A CIDADE COMO NEGÓCIO

EURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales, 2013
As transformações atuais das grandes metrópoles vêm adquirindo um certo destaque na agenda da pesquisa urbana. Inserindo-se nesse debate, este artigo analisa o novo protagonismo do capital imobiliário no desenvolvimento dessas cidades, a partir de um ...
Inaiá de Carvalho, Gilberto Corso-Pereira   +1 more
doaj   +1 more source

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib, Luis Felipe Hernández‐Ayala, Silvana Silva‐Aguirre, Annia Galano   +3 more
wiley   +1 more source

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

Testing the Dry Refuge Model: Paleoecological Insights From Late Pleistocene Gomphotheres in Ecuador

Ecology and Evolution, Volume 16, Issue 8, August 2026.
We present paleontological evidence that may prove the Dry Refuge Model in Ecuador during the Late Pleistocene. ABSTRACT Paleoenvironmental records indicate that Neotropical regions near the Equator experienced reduced rainfall during the Last Glacial Maximum (LGM). However, some records show conflicting environmental signals.
Erwin González‐Guarda, Iván Ramírez‐Pedraza, Carlos Tornero, Lidiane Asevedo, Natalia Villavicencio, Sebastián Escobar, José Luis Román, Melissa Hidalgo, Esteban Benalcázar, Florent Rivals   +9 more
wiley   +1 more source

La gobernanza metropolitana y el reto del desarrollo urbano-territorial sostenible: las experiencias en Alemania

Ciência & Trópico, 2019
El presente trabajo tiene el objetivo de ofrecer un análisis de la gobernanza y planificación territorial en las áreas metropolitanas en Alemania, para contribuir a la difusión del conocimiento sobre las experiencias obtenidas en este país, que por ...
Andreas Hildenbrand
doaj   +1 more source

Probiotic Stability and Antihypertensive Activity of Peptides in Aguamiel Syrup‐Fortified Milk Protein Fermented by Lacticasebacillus rhamnosus GG

eFood, Volume 7, Issue 4, August 2026.
This study evaluates the impact of aguamiel syrup on a synbiotic fermented dairy product, focusing on antihypertensive peptide release and Lacticaseibacillus rhamnosus GG survival. While metabolic parameters remained unchanged, aguamiel syrup enhanced bioactive peptide production and antihypertensive activity (45.3%), suggesting its potential as a ...
Olvera‐Rosales Laura Berenice, Leonel‐Enríquez Jorge Eduardo, Pérez‐Escalante Emmanuel, Castañeda‐Ovando Araceli, Contreras‐López Elizabeth, Cruz‐Guerrero Alma Elizabeth, González‐Olivares Luis Guillermo   +6 more
wiley   +1 more source

From Crisis to Resilience: Rethinking Urban Flooding and Groundwater Recharge in Bengaluru City, India

World Water Policy, Volume 12, Issue 3, August 2026.
ABSTRACT Bengaluru, a primary metropolitan centre in India, is currently grappling with the dual crises of urban flooding and severe groundwater depletion. These challenges are driven by rapid urbanization, which has seen built‐up areas increase from 42% to 86% over two decades, resulting in a dramatic loss of vegetation and wetlands.
S. Biswas, S. V. B. Patel, B. Maheshwari
wiley   +1 more source