Results 151 to 160 of about 5,240 (237)

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

open access: yesMedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele   +7 more
wiley   +1 more source

Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer

open access: yesMedComm, Volume 7, Issue 6, June 2026.
This study performed whole‐exome sequencing, proteomic, and phosphoproteomic analysis on 80 pairs of tumor tissues and matched normal adjacent tissues from colorectal cancer patients. The integrated proteogenomic study provides a comprehensive and nuanced understanding of the molecular heterogeneity between left‐ and right‐sided colorectal cancer ...
An Huang   +11 more
wiley   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu   +3 more
wiley   +1 more source

Planetary Health Diet Adherence Improves Weight and Body Composition During Energy Restriction

open access: yesObesity, Volume 34, Issue 6, Page 1265-1276, June 2026.
ABSTRACT Objective Obesity management relies on energy restriction, yet the contribution of dietary quality to weight‐loss and body composition outcomes during hypocaloric interventions remains poorly characterized. This study evaluated whether adherence to the Planetary Health Diet (PHD), as a measure of diet quality, and its key components is ...
Paola Mogna‐Peláez   +13 more
wiley   +1 more source

When invasions go unnoticed: Public perception of the freshwater jellyfish Craspedacusta sowerbii in Europe

open access: yesPeople and Nature, Volume 8, Issue 6, Page 1957-1973, June 2026.
Abstract Biological invasions are a major driver of biodiversity loss, yet inconspicuous or “cryptic” species often escape detection and public awareness, limiting management responses. We investigated the freshwater jellyfish Craspedacusta sowerbii, likely native to China and now present on six continents, through a 22‐month multilingual online survey
Guillaume Marchessaux   +17 more
wiley   +1 more source

Single Cu Atom Sites on Co3O4 Activate Interfacial Oxygen for Enhanced Reactivity and Selective Gas Sensing at Low Temperature

open access: yesSmall, Volume 22, Issue 32, 8 June 2026.
Atomically dispersed Cu sites on Co3O4 nanoparticles establish well‐defined Cu–O–Co interfacial linkages that promote lattice oxygen activation at markedly reduced temperatures. This structural and electronic modulation yields over twenty‐fold higher low‐temperature formaldehyde sensing responses than CuO nanoparticle analogues, enabling selective and ...
Hamin Shin   +7 more
wiley   +1 more source

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