Results 221 to 230 of about 84,635 (252)

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

The Incidence of Contrast-Induced Nephropathy Among Low-Risk Cancer Patients with Preserved Renal Function on Active Treatment Undergoing Contrast-Enhanced Computed Tomography: A Single-Site Experience. [PDF]

Healthcare (Basel)
Subahi A, Alhazmi N, Lardi M, Alkathiri F, Bokhari L, Alqahtani S, Abourokba N, Alshamrani K.   +7 more
europepmc   +1 more source

Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First‐Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model

MedComm, Volume 7, Issue 3, March 2026.
Chemotherapy is the mainstay in the treatment of advanced gastric cancer (GC); yet, GC showed diverse responses to first‐line chemotherapy regimens and the underlying molecular basis is still not clear. Here, we established a system that combined organoid‐based chemotherapy regimen screening and transcriptome‐based evaluation to identify underlying ...
Jingwei Yang, Shuyue Qi, Yuan Gao, Jiansen Lu, Lin Deng, Xinglong Wu, Yifei Zhao, Yun Liu, Yanpeng Ma, Jiagui Song, Lixiang Xue, Lu Wen, Wei Fu, Fuchou Tang, Xin Zhou   +14 more
wiley   +1 more source

Comparison of intravenous hydration and oral hydration in preventing contrast-induced nephropathy among patients undergoing peripheral vascular interventions. [PDF]

BMC Nephrol
Liu J, Zhu H, Liu L.
europepmc   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase. [PDF]

Cancer Discov
Bai Y, Agustinus AS, Yomtoubian S, Meydan C, McNally DR, Yoffe L, Hubisz MJ, Tranquille M, Pramod S, Hong C, Plasilova ML, Kapoor AR, Singh A, Withers H, Dow LE, Laughney AM, Bhinder B, Elemento O, Melnick AM, Bakhoum SF, Mittal V.   +20 more
europepmc   +1 more source

Ultrasonography in General Practice: Insights From an Implementation Study in a Low‐Income Neighborhood of Amsterdam

Sonography, Volume 13, Issue 1, March 2026.
ABSTRACT Background Ultrasonography is increasingly being used in primary care settings, facilitated by technological advancements, reduced device‐related costs, and improved access to training and support. It holds particular promise for underserved communities, where barriers such as co‐pays or long waiting lists can limit access to diagnostic ...
Ralf E. Harskamp, Britt Soddemann genaamd Keute, Constantijn Pleiter, Jelle C. L. Himmelreich   +3 more
wiley   +1 more source

A genome-wide RNAi screen for novel CIN genes using human artificial chromosome. [PDF]

PNAS Nexus
Liskovykh M, Kochanova NY, Chiang CY, Dhall A, Aksenova V, Chen YC, Reinhold WC, Dasso M, Thomas A, Cheng KC, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.   +13 more
europepmc   +1 more source

High‐resolution quantitative trait loci mapping and pyramiding effects of candidate genes for plant height in soybean

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Plant height is a crucial agronomic trait that significantly influences plant architecture and yield in soybean (Glycine max (L.) Merr.). Identifying major genes regulating plant height and developing closely linked molecular markers are crucial for breeding soybean cultivars with ideal architecture.
Dan Sha, Zhenzhen Zhang, Yongzhe Gu, Shengrui Zhang, Aimal Nawaz Khattak, Yitian Liu, Caiyou Ma, Meng Hu, Jimeng Niu, Linfeng Yu, Shibi Zhang, Azhar Iqbal, Ahsan Muhammad, Jing Li, Junming Sun, Rongxia Guan, Bin Li   +16 more
wiley   +1 more source