Results 51 to 60 of about 190,671 (235)

Nanoporous Silica Embedded in Nanoporous Platinum: A Versatile Composite Coating for Implant‐Associated Drug Delivery From Neuronal Electrodes

open access: yesAdvanced Materials Technologies, EarlyView.
Nanoporous silica nanoparticles incorporated in nanoporous platinum offer the possibility for implant‐associated drug delivery from neuronal electrodes. ABSTRACT Sensorineural hearing loss, resulting from damage to the hair cells of the inner ear, profoundly impairs quality of life.
Mosaieb Habib   +10 more
wiley   +1 more source

El Mercurio y la prensa obrera: Dos enfoques periodísticos para construir nación

open access: yesCorrespondencias & Análisis, 2013
Los medios de comunicación ayudan a construir simbólicamente la nación, principalmente a través de su acción en el ámbito de la cultura y a través de ella en las más diversas facetas y planos del quehacer ciudadano.
Fernando Rivas Inostroza
doaj   +1 more source

Multimodal Human–Robot Interaction Using Human Pose Estimation and Local Large Language Models

open access: yesAdvanced Robotics Research, EarlyView.
A multimodal human–robot interaction framework integrates human pose estimation (HPE) and a large language model (LLM) for gesture‐ and voice‐based robot control. Speech‐to‐text (STT) enables voice command interpretation, while a safety‐aware arbitration mechanism prioritizes gesture input for rapid intervention.
Nasiru Aboki   +2 more
wiley   +1 more source

Anatomía de unos gobiernos independentistas

open access: yesHistoria del Presente, 2020
Desde 2010, las fuerzas nacionalistas catalanas han protagonizado una marcada y acelerada apuesta política e institucional para la independencia de Cataluña.
Paola Lo Cascio
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Le cœur du pouvoir exécutif : des dirigeants aux profils très élitistes. Les actions en faveur d’une représentation plus diverse

open access: yesCahiers du MIMMOC, 2014
Cet article se propose d’analyser le profil des dirigeants politiques en Grande-Bretagne à partir de leurs caractéristiques socio-économiques et éducatives.
Karine RIVIÈRE-DE FRANCO
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

open access: yesAdvanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj   +25 more
wiley   +1 more source

Formation d'une élite paysanne au Burkina Faso

open access: yes, 2015
Les paysans des projets constituent-ils une élite ? Si oui, quel genre d'élite ? Mais sont-ils encore des paysans ? Telles sont les questions clés que se pose Sadamba Tcha-Koura, un sociologue togolais, dans son ouvrage « Formation d'une élite..
Technical Centre for Agricultural and Rural Cooperation
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

open access: yesAdvanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters   +12 more
wiley   +1 more source

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