Results 231 to 240 of about 4,466,005 (254)

Definitions, references and interpretations of the concept of multifunctionality and its contributions to a sustainable development : Summary report. International analysis of MFA, international negotiations and sustainable development [PDF]

, 2005
Aumand, Anthony, Barthélémy, Denis, Caron, Patrick, Le Cotty, Tristan   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Impact of dental loupes and operating microscopes on restorative performance of preclinical and clinical dental students: a pilot study. [PDF]

BMC Med Educ
Prause E, Rechlin J, Peroz S, Steinke A, von Stein-Lausnitz M, Beuer F.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Standardized neutralizing antibody assay for Coxsackievirus A10 in clinical trial: A framework for multivalent hand, foot, and mouth disease vaccine evaluation. [PDF]

Hum Vaccin Immunother
Wang Q, Li L, Gao J, Liu M, Wang Y, He Q, Wang W, Li Y, Gu M, Xie Z, Liu Q, Han J, Zhang Z, Guo J, Wu X, Mao Q, Chen X, Liang Z, Gao F, Ma X.   +19 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Implementing an eHealth Model of Care for Pediatric Patients and Families at the End of Treatment for Acute Lymphoblastic Leukemia (EMERGE): Type 2 Nonrandomized Hybrid Implementation-Effectiveness Trial Study Protocol.

JMIR Res Protoc
McCarthy MC, Williams C, Tennant M, De Abreu Lourenco R, Pring H, Moore K, Templeton J, Knight K, Downie P, Hearps S, De Luca C.   +10 more
europepmc   +1 more source

DispatchMAS: fusing taxonomy and artificial intelligence agents for emergency medical services. [PDF]

BMC Emerg Med
Li X, Yu H, Wang W, Wu Y, Zhou J, Hua W, Lin X, Tan W, Zhu L, Chen B, Chen G, Chen ML, Zhou Y, Li Z, Assimes TL, Zhang Y, Wu Q, Ma X, Li L, Fan L.   +19 more
europepmc   +1 more source

Le suivi-évaluation [PDF]

, 2010
Casabianca, François, Kwa, Moïse, Temple, Ludovic   +2 more
core