Results 81 to 90 of about 104 (98)

Xstainer: A Novel Virtual Staining Tool Powered by Advanced Deep Learning Techniques

Advanced Intelligent Systems, EarlyView.
Xstainer is a deep learning–based virtual staining framework that converts hematoxylin and eosin‐stained whole slide images into multiple histochemical stains, including Masson's trichrome, Periodic acid‐Schiff, Jones methenamine silver, and Toluidine blue.
Fatma Nur Kinali, Derya Demir, Kutsev B. Ozyoruk, Yasin Almalioglu, Emre C. Kose, Drew F. K. Williamson, Gurdeniz Serin, G. Evren Keles, Banu S. Kumbaraci, Ceren Utku, Uguray P. Hacisalihoglu, Ilknur Turkmen, Figen Ozturk, Kayhan Basak, Yavuz Nuri Ertas, Mehmet Turan   +15 more
wiley   +1 more source

Dithioketal Polymers Via Radical Polymerization of γ‐Dithiobutyrolactone

Angewandte Chemie, EarlyView.
γ‐Dithiobutyrolactone (DTBL) behaves like a ring‐retaining monomer in radical copolymerization with a series of conjugated monomers like styrene, t‐butyl acrylate and N,N‐dimethylacrylamide. The resulting copolymers contain controlled fractions of dithioketal linkages in their backbone, allowing chemical degradation.
Maksym Odnoroh, Oleksandr Ivanchenko, Asja A. Kroeger, Michelle L. Coote, Stéphane Mazières, Mathias Destarac   +5 more
wiley   +2 more sources

The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli, Giulia Bruna Marchetti, Maria Iascone, Maria Grazia Patricelli, Sara Giangiobbe, Gabriella Cinzia Pozzobon, Miriam Nella Savini, Fabio Giglio, Alessandro Aiuti, Paola Carrera, Francesca Ferrua, Angela Peron   +11 more
wiley   +1 more source

Mechanically Induced Switching Between Orbital‐ and Fano‐Resonance Rectification in a Dual‐Anchored Molecular Junction

Angewandte Chemie, EarlyView.
Mechanical control of anchoring chemistry enables switching between orbital‐driven and interference‐driven rectification in a single‐molecule junction. ABSTRACT Achieving precise control over charge transport through individual molecules is central to advancing single‐molecule electronics.
Xin Sun, Ran Liu, Samjhana Maharjan, Sneha Kindapal, Guang Yang, Feng Sun, Chuan‐Kui Wang, A. Jean‐Luc Ayitou, Bingqian Xu   +8 more
wiley   +2 more sources

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

Programming Palladium Cage Geometry through Ligand Redox Modulation

Angewandte Chemie, EarlyView.
A neutral redox‐active exTTF ligand (L) forms a Pd2L4 cage, whereas its oxidized form (Lox) yields a Pd2(Lox)2 macrocycle. Lox further assembles with a dibenzothiophene derivative (L′) into Pd2(Lox)(L′)2 and Pd4(Lox)4(L′)4 architectures. Reduction of Pd2(Lox)2 and Pd2(Lox)(L′)2 restores the parent Pd2L4 cage, enabling redox controlled nuclearity ...
Jennifer Bou Zeid, Jean Nicolas, Maksym Dekhtiarenko, David Canevet, Magali Allain, Vincent Carré, Frédéric Aubriet, Laura Neukirch, Elie Benchimol, Marc Sallé, Guido H. Clever, Sébastien Goeb   +11 more
wiley   +2 more sources

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Design Rules for Controlling Connectivity, Topology, and Sorting Using Hydrogen‐Bonded Pairs and Aromatic Components in Palladium(II)‐Based Interlocked and Foldameric Systems

Angewandte Chemie, EarlyView.
We have established a set of design rules which combine Pd(II) metal coordination, complementary geometries, complementary interligand hydrogen bonding and π─π interactions for predictable self‐assembly of Pd(II)‐based species such as metallo‐foldamers, cyclic species a metallo‐interlocked clippane. The species persist in a combinatorial mixture due to
Jess L. Algar, Jordan N. Smith, Dan Preston   +2 more
wiley   +2 more sources

Boron‐Doping of a Macrocyclic Tetrafuran Framework Unveils an Expanded Porphyrinoid With Switchable (Anti)Aromaticity and Conformational Dynamics

Angewandte Chemie, EarlyView.
We disclose a novel boron macrocycle derived from the sustainable furan building block. The boraporphyrinoid exhibits a global antiaromatic ring current and dynamic conformational flexibility. Twofold reduction induces a switch to strong global aromaticity, accompanied by stiffening of the porphyrinoid backbone.
Lukas Swoboda, Jonas Klopf, Jonas Bachmann, Ivo Krummenacher, Holger Braunschweig, Bernd Engels, Holger Helten   +6 more
wiley   +2 more sources

An Artificial Molecular Pump Powered by Light

Angewandte Chemie, EarlyView.
A minimal rotaxane‐based supramolecular system functions as a light‐powered molecular pump, capturing macrocycles from solution and concentrating them within an intramolecular compartment. Repeated azobenzene photoisomerization modulates the binding and kinetic barriers of threading and shuttling, generating a photon‐driven energy ratchet that sustains
Federico Nicoli, Chiara Taticchi, Stefano Corra, Marina Tranfić Bakić, Massimo Baroncini, Serena Silvi, Jessica Groppi, Alberto Credi   +7 more
wiley   +2 more sources