Results 101 to 110 of about 5,871,692 (281)

Aẓar deg tmaziγt d allal n usileγ n tayunin timaynutin

Langues & Cultures
Deg tmaziɣt, asileɣ n umawal ibedd ɣef sin n yikalayen igejdanen : asuddem d usuddes. Maca, mi ara nmuqqel ɣer wuṭṭun n tayunin i d-yettalɣen, ad d-negzu dakken yella lexṣaṣ deg tayunin n umawal imi addayen n usuddem drus i yellan, d ayen i ɣ-yettawin ...
Mahdi YAHIAOUI
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Characterizing N-type derivations on standard operator algebras by local actions

AIMS Mathematics
On an infinite dimensional complex Hilbert space $ \mathcal{H} $, we consider a standard operator algebra $ \mathcal{S} $ with an identity operator $ I $ that is closed with respect to adjoint operation.
Khalil Hadi Hakami , Junaid Nisar , Kholood Alnefaie , Moin A. Ansari   +3 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Истина, скрытая в букваÑ

, 2020
КÐμÐ ⁄ уРь БУНЬР̄ДЗАДЕ
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Crystal structure of 4,4′-(4,10-diphenyl-4,10-dihydropyreno[4,5-d:9,10-d′]diimidazole-5,11-diyl)bis(N,N-diphenylaniline), C66H44N6

Zeitschrift für Kristallographie - New Crystal Structures, 2018
C66H44N6, triclinic, P1̄ (no. 2), a = 9.773(2) Å, b = 14.406(3) Å, c = 18.385(4) Å, α = 72.64(3)°, β = 82.10(3)°, γ = 76.90(3)°, V = 2399.5(8) Å3, Z = 2, Rgt(F) = 0.0546, wRref(F2) = 0.1559, T = 153(2) K.
Liu Yulong, Dong Zhaojia, Guo Youquan, Fu Ying   +3 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Улога на тиреоидното ткиво на блаÑÑ‚-транÑфорамцијата на лимфоцитите на болни Ñо тиреотокÑикоза

, 2017
It has been examined the possibility of thyroid tissue as to how as a same antigen influence on blast - transformation, eventually on previously sensitised lymphocytes at thyrotoxicosis patients.The lymphocytes have been separated (taken) from the vein ...
Малинова (Malinova), Љубинка (Ljubinka), КаранфилÑки (Karanfilski), БориÑлав (Borislav)   +1 more
core  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source