Results 11 to 20 of about 357 (111)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Position‐dependent offset corrections for ring applicator reconstruction in cervical cancer brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Due to the tight curvature in their design, ring applicators are usually associated with large positioning errors. The standard practice to correct for these deviations based on global offsets may not be sufficient to comply with the recommended tolerance.
Leon G. Aldrovandi, Matthias E. T. Dessein, Shelley M. Pearson, Shelley M. Bulling   +3 more
wiley   +1 more source

Vivid Structural Coloration in Transparent MXene‐Cellulose Nanocrystals Composite Films

Advanced Functional Materials, EarlyView.
Vivid structural coloration in reflectance and high transparency in transmittance modes are observed in biopolymer‐layered composite films. The ultrathin multilayered structures have unique optical appearance, near‐infrared bandgap, and strong optical reflection caused by alternating MXene and cellulose nanocrystals layers with high refractive index ...
Botyo Dimitrov, Valeriia Poliukhova, Claire Joo, Madeline Buxton, Irina Roslyk, Yury Gogotsi, Jacob Crossno, Kirt A. Page, Hilmar Koerner, Dhriti Nepal, Michael E. McConney, Timothy J. Bunning, Vladimir V. Tsukruk   +12 more
wiley   +1 more source

Circularly Polarized Perovskite Photodetector with Photocurrent Dissymmetry Factors of up to 1.95 Enabled by Liquid Crystal

Advanced Functional Materials, EarlyView.
Photodetectors made using perovskite single crystals in combination with free‐standing cholesteric liquid crystal (CLC) polymer films exhibit photocurrent dissymmetry factors up to 1.95 for 520 nm circularly polarized light (CPL) excitation. The CPL spectral response of the photodetector is tunable over a broad range of wavelengths by tuning the ...
Yifan Feng, Guanfeng Gao, Xuebing Wen, Zekai Chen, Jiaqi Huang, Chao Yang, Xiao‐Fang Jiang, Lakshminarayana Polavarapu, Guofu Zhou, Xiaowen Hu   +9 more
wiley   +1 more source

Active Learning‐Driven Discovery of Sub‐2 Nm High‐Entropy Nanocatalysts for Alkaline Water Splitting

Advanced Functional Materials, EarlyView.
High‐entropy nanoparticles (HENPs) hold great promise for electrocatalysis, yet optimizing their compositions remains challenging. This study employs active learning and Bayesian Optimization to accelerate the discovery of octonary HENPs for hydrogen and oxygen evolution reactions.
Sakthivel Perumal, Da Bean Han, Thandapani Marimuthu, Taewaen Lim, Hyun Woo Kim, Junhyeok Seo   +5 more
wiley   +1 more source

Quantum Emitters in Hexagonal Boron Nitride: Principles, Engineering and Applications

Advanced Functional Materials, EarlyView.
Quantum emitters in hexagonal boron nitride have emerged as a promising candidate for quantum information science. This review examines the fundamentals of these quantum emitters, including their level structures, defect engineering, and their possible chemical structures.
Thi Ngoc Anh Mai, Md Shakhawath Hossain, Nhat Minh Nguyen, Yongliang Chen, Chaohao Chen, Xiaoxue Xu, Quang Thang Trinh, Toan Dinh, Toan Trong Tran   +8 more
wiley   +1 more source

Synthetic Control of Water‐Stable Hybrid Perovskitoid Semiconductors

Advanced Materials, EarlyView.
Hybrid metal‐halide perovskites are promising semiconductors for optoelectronics, yet their water stability is problematic. A new synthesis method is developed using lead iodide and cysteamine under various pH conditions, forming stable perovskitoid structures.
Jiyoon Kim, Soumyadeep Ghosh, Nicholas W. G. Smith, Sunhao Liu, Yixuan Dou, Carla Slebodnick, Giti A. Khodaparast, Jin Qian, Lina Quan   +8 more
wiley   +1 more source

Fatigue‐Resistant Mechanoresponsive Color‐Changing Hydrogels for Vision‐Based Tactile Robots

Advanced Materials, EarlyView.
Mechanoresponsive color‐changing materials that can reversibly and resiliently change color in response to stress are highly desirable for diverse technologies in optics, sensors, and robots; however, such materials are rarely achieved. This work reports a fatigue‐resistant mechanoresponsive color‐changing hydrogel that exhibits reversible, resilient ...
Jiabin Liu, Wei Li, Yu She, Sean Blanchard, Shaoting Lin   +4 more
wiley   +1 more source

The Structure‐Mechanics Relationship of Bamboo‐Epidermis and Inspired Composite Design by Artificial Intelligence

Advanced Materials, EarlyView.
This article investigates the micromechanics of bamboo epidermis, focusing on how anisotropic silica particle distributions enhance toughness. By integrating experimental imaging, 3D printing, and generative AI, the study develops bio‐inspired particle‐reinforced composites with mechanical properties akin to bamboo.
Zhao Qin, Aymeric Pierre Destree
wiley   +1 more source