Results 41 to 50 of about 357 (111)

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
wiley   +1 more source

Electrostatically Reinforced Double Network Granular Hydrogels

Advanced Science, EarlyView.
Electrostatically reinforced double network granular hydrogels (DNGHs) with cartilage‐like fracture energy are introduced. An empirical model predicts the composition‐dependent fracture energy based on dissipation zone size, contact area, and inter‐particle adhesion energy. Thanks to their granular structure and the inter‐particle attraction, the DNGHs
Tianyu Yuan, Chenzhuo Li, John M. Kolinski, Esther Amstad   +3 more
wiley   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source

Facile Fabrication of Large‐Area and High‐Quality Organic–Inorganic Hybrid Perovskite Ferroelectric Films Through Electrohydrodynamic Printing

Advanced Science, EarlyView.
In situ fabrication of large‐area, high‐quality organic‐inorganic hybrid perovskite ferroelectric (OIHPF) crystals and films via on‐demand electrohydrodynamic (EHD) printing modes. Abstract Traditional oxide ferroelectrics have long struggled to produce flexible, large‐area, and high‐quality thin films at low temperatures, despite their good ...
Jingjing Luo, Zhongqi Ren, Xue Qi, Qiang Pan, Dong Li, Yuan Xiong, Jie Yao, Haipeng Liu, Suzhu Yu, Jun Wei   +9 more
wiley   +1 more source

In Situ Control of Reactive Mesogens Alignment During 3D Printing by Two‐Photon Lithography

Advanced Science, EarlyView.
Manipulating material properties at the microscale is crucial for 3D printing of smart microdevices. Two‐photon lithography directly patterns molecular alignment in liquid crystal resists. The polymerization reaction wavefront along the writing path induces an easy‐axis for the mesogenic moieties.
Tiziana Ritacco, Alfredo Mazzulla, Michele Giocondo, Gabriella Cipparrone, Pasquale Pagliusi   +4 more
wiley   +1 more source

Confined Migration Drives Stem Cell Differentiation

Advanced Science, EarlyView.
Human mesenchymal stem cell (hMSC) homing to sites of regeneration requires navigation through mechanically confining extracellular matrix environments, inducing rapid and dramatic morphological adaptation. By exposing hMSCs to specific levels of physiological confinement, it is demonstrated that confinement can induce osteogenesis, and that this fate ...
Xu Gao, Yixuan Li, Jia Wen Nicole Lee, Jianxuan Zhou, Vaishnavi Rangaraj, Jennifer Marlena, Andrew W. Holle   +6 more
wiley   +1 more source

Silicon Carbide Photonic Crystal Photoelectrode

Advanced Science, EarlyView.
A 3C‐SiC photoelectrode with a slanted parabolic pore photonic crystal architecture enhances photogeneration for efficient photoelectrochemical water splitting through the remarkable light‐trapping capabilities of photonic crystal slow‐light modes.
Xiwen Zhang, Sajeev John
wiley   +1 more source