Results 91 to 100 of about 6,284,543 (247)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Revision of the carnivorous snail genus Discartemon Pfeiffer, 1856, with description of twelve new species (Pulmonata, Streptaxidae)

ZooKeys, 2014
Twelve new species of the streptaxid snail genus Discartemon Pfeiffer, 1856 are described from southern Thailand and western Malaysia, D. afthonodontia sp. n., D. circulus sp. n., D. deprima sp. n., D. discadentus sp. n., D. discamaximus sp.
Thanit Siriboon, Chirasak Sutcharit, Fred Naggs, Ben Rowson, Somsak Panha   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

БезбедноÑта во Ñообраќајот на патиштата – предизвици за јавноздравÑтвен одговор [PDF]

, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Тозија (Tozija), Фимка (Fimka)
core   +1 more source

Food Allergy Based on Serum Specific IgE in Republic of Macedonia [PDF]

, 2015
ОСÐОВÐ:  Ðлергијата кон храна Ñе дефинира како неÑакан имун одговор кој Ñе јавува при повторувачки изложувања на било кој вид на храна и може д
Efinska-Mladenovska, Olivija, Hristomanova Mitkovska, Slavica, Petlichkovski, Aleksandar, Spiroski, Mirko, Trajkov, Dejan   +4 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Верификација на квалитативни методи Ñо теÑÑ‚ ленти за иÑпитување на дроги кои Ñе злоупотребуваат во урина [PDF]

, 2018
The verification of the  qualitative method with test  devices for detection of eight drugs of abuse in urine  (amphetamines, methamphetamine,  barbiturates,  benzoylecgonine,  marijuana, 3,4-methylendioxy-methamphetamine, methadone, and opiates) was ...
ТопузовÑка (Topuzovska), Соња (Sonja), ТошеÑка-ТрајковÑка (Tosheska-Trajkovska), Катерина (Katerina), ЦековÑка (Cekovska), Светлана (Svetlana), БогданÑка (Bogdanska), ЈаÑна (Jasna), Лабудовиќ (Labudovik), Даница (Danica)   +4 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Boundedness of strong maximal functions with respect to non-doubling measures

Journal of Inequalities and Applications, 2016
The main purpose of this paper is to establish a boundedness result for strong maximal functions with respect to certain non-doubling measures in R n $\mathbb{R}^{n}$ . More precisely, let d μ ( x 1 , … , x n ) = d μ 1 ( x 1 ) ⋯ d μ n ( x n ) $d\mu(x_{1},
Wei Ding, LiXin Jiang, YuePing Zhu
doaj   +1 more source

A Historical Writing Apprenticeship for Adolescents: Integrating Disciplinary Learning With Cognitive Strategies [PDF]

, 2016
This study explored the extent to which an 18â day history and writing curriculum intervention, taught over the course of one year, helped culturally and academically diverse adolescents achieve important disciplinary literacy learning in history ...
Croninger, Robert, De La Paz, Susan, Felton, Mark, Jackson, Cara, Monte‐sano, Chauncey, Piantedosi, Kelly Worland   +5 more
core   +1 more source