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Results 11 to 20 of about 175 (172)

, 2017
Studies of the early 21st century indicate that the decline in cognitive functionis as a complication of anesthesia and operative intervention. Whether there would be changes and the amount of changes in mental status will cause a type of anesthesia is a
Ð¢Ñ€Ð°Ñ˜ÐºÐ¾Ð²Ð°, Ð Ð°Ð´Ð¼Ð¸Ð»Ð° +2 more
core +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif +17 more
wiley +1 more source

Data‐driven forecasting of ship motions in waves using machine learning and dynamic mode decomposition

International Journal of Adaptive Control and Signal Processing, EarlyView.
Summary Data‐driven forecasting of ship motions in waves is investigated through feedforward and recurrent neural networks as well as dynamic mode decomposition. The goal is to predict future ship motion variables based on past data collected on the field, using equation‐free approaches.
Matteo Diez, Mauro Gaggero, Andrea Serani +2 more
wiley +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li +10 more
wiley +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
wiley +1 more source

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ÐœÐ•ÐÐ•Ð”Ð–ÐœÐ•ÐÐ¢ ÐšÐ£Ð›Ð¬Ð¢Ð£Ð Ð« Ð’ ÐœÐÐ›ÐžÐœ Ð‘Ð˜Ð—ÐÐ•Ð¡Ð• Ð Ð•Ð¡ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ˜ ÐœÐžÐ›Ð”ÐžÐ’Ð

Ð•Ð’ÐÐ›Ð£ÐÐ¦Ð˜ÐˆÐ ÐÐ ÐŸÐ ÐžÐ“Ð ÐÐœÐ˜Ð¢Ð• Ð—Ð ÐŸÐ Ð•Ð’Ð•ÐÐ¦Ð˜ÐˆÐ ÐÐ ÐœÐÐ›Ð˜Ð“ÐÐ˜ ÐÐ•ÐžÐŸÐ›ÐÐ—ÐœÐ˜ Ð’Ðž Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ (2005-2015) [PDF]

computer applications to medicine
medical informatics