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Results 21 to 30 of about 400 (179)

, 2017
Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ÐÐ»ÑƒÐ»Ð¾ÑÐºÐ¸, Ð˜Ð³Ð¾Ñ€
core +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source

ÐŸÐ Ð˜Ð¡Ð¢ÐÐŸ Ð”Ðž Ð‘Ð•Ð—Ð‘Ð•Ð”ÐÐ Ð’ÐžÐ”Ð Ð—Ð ÐŸÐ˜Ð•ÐŠÐ• Ð’Ðž Ð¡Ð•Ð’Ð•Ð ÐžÐ˜Ð¡Ð¢ÐžÐ§ÐÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ ÐÐ Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ- Ð Ð•Ð¢Ð ÐžÐ¡ÐŸÐ•ÐšÐ¢Ð˜Ð’ÐÐ ÐÐÐÐ›Ð˜Ð—Ð [PDF]

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu +9 more
wiley +1 more source

Ð•Ð’ÐÐ›Ð£ÐÐ¦Ð˜ÐˆÐ ÐÐ ÐŸÐ ÐžÐ“Ð ÐÐœÐ˜Ð¢Ð• Ð—Ð ÐŸÐ Ð•Ð’Ð•ÐÐ¦Ð˜ÐˆÐ ÐÐ ÐœÐÐ›Ð˜Ð“ÐÐ˜ ÐÐ•ÐžÐŸÐ›ÐÐ—ÐœÐ˜ Ð’Ðž Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ (2005-2015) [PDF]

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