Results 11 to 20 of about 197 (195)

In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao, Samuel J. Teener, Ian F. Webber‐Davis, Lili Zhao, Eva L. Feldman, Stephen A. Goutman   +8 more
wiley   +1 more source

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif, Georgios Mangioris, Binxia Yang, Vanessa K. Pazdernik, Jeffrey W. Britton, Divyanshu Dubey, Eoin P. Flanagan, Sarosh R. Irani, Gregory S. Day, Charles L. Howe, A. Sebastian López‐Chiriboga, Andrew McKeon, John R. Mills, Yahel Segal, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +17 more
wiley   +1 more source

Data‐driven forecasting of ship motions in waves using machine learning and dynamic mode decomposition

International Journal of Adaptive Control and Signal Processing, EarlyView.
Summary Data‐driven forecasting of ship motions in waves is investigated through feedforward and recurrent neural networks as well as dynamic mode decomposition. The goal is to predict future ship motion variables based on past data collected on the field, using equation‐free approaches.
Matteo Diez, Mauro Gaggero, Andrea Serani   +2 more
wiley   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuella Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Wearable Haptic Feedback Interfaces for Augmenting Human Touch

Advanced Functional Materials, EarlyView.
The wearable haptic feedback interfaces enhance user experience in gaming, social media, biomedical instrumentation, and robotics by generating tactile sensations. This review discusses and categorizes current haptic feedback interfaces into force, thermal, and electrotactile stimulation‐based haptic feedback interfaces, elucidating their current ...
Shubham Patel, Zhoulyu Rao, Maggie Yang, Cunjiang Yu   +3 more
wiley   +1 more source

Stable and Dendrite‐Free Zinc Metal Anodes Via Interface Nanoarchitectonics for Aqueous Zinc‐Ion Batteries

Advanced Functional Materials, EarlyView.
This review explores Zn anode challenges in aqueous ZIBs, including dendrites, corrosion, and side reactions, and discusses strategies for improvement through Zn anode, electrolyte, and separator modifications to enhance stability and efficiency. Abstract Aqueous rechargeable zinc‐ion batteries (ZIBs) are emerging as promising candidates for next ...
Pragati A. Shinde, Nilesh R. Chodankar, Lok Kumar Shrestha, Amal Al Ghaferi, Ebrahim Alhajri, Katsuhiko Ariga   +5 more
wiley   +1 more source

Novell Ñе здружува Ñо lntel [PDF]

, 2016
изваР...
информатика, МЕДИС -
core   +1 more source

ПОДГОТОВКА СТУДЕНТОВ К ПРОФЕССИОНАЛЬНОЙ ИННОВАЦИОННОЙ ДЕЯТЕЛЬНОСТИ В РАМКАХ СПЕЦИАЛЬНОГО УЧЕБНОГО КУРСА

Mokslo Taikomieji Tyrimai Lietuvos Kolegijose, 2016
Наметившиеся в последнее время тенденции к универсализации образования, прагматичный подход и ориентирование на потребителя, Ð¾Ð¿Ñ€ÐµÐ´ÐµÐ»ÑÑŽÑ ...
Елена Василевская
doaj  

Adobe ги здружува Ñилите Ñо Netscape [PDF]

, 2016
изваР...
информатика, МЕДИС -
core   +1 more source