Results 191 to 200 of about 6,164,401 (205)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mapping implementation barriers and facilitators of a physical activity consultation in the Portuguese primary healthcare: a qualitative approach combining the Tailored Implementation for Chronic Diseases and Behaviour Change Wheel frameworks. [PDF]

BMJ Open
Silva CS, Silva MN, Encantado J, Franco S, Rosa BA, Mendes R, Teixeira PJ, Godinho CA.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cycloruthenated Imines: A Step into the Nanomolar Region. [PDF]

Molecules
Vasil'ev AA, Troshin II, Shangin PG, Voroshilkina KM, Shutkov IA, Nazarov AA, Medved'ko AV.   +6 more
europepmc   +1 more source

Nomogram-based analysis of plasma albumin and C-reactive protein 30 days before bloodstream infection for 30-day mortality in Singapore and Denmark. [PDF]

Sci Rep
Phua ZJ, Aung AH, Sim PJW, Coia JE, Chen M, Nielsen SL, Jensen TG, Møller JK, Dessau RB, Póvoa P, Gradel KO, Chow A.   +11 more
europepmc   +1 more source

Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial. [PDF]

Diabetes Care
Mann JFE, Marx N, Deanfield JE, Emerson SS, Inzucchi SE, McGuire DK, Mulvagh SL, Pop-Busui R, Poulter NR, Engelmann MDM, Hovingh GK, Belmar N, Idorn T, Jeppesen OK, Birkenfeld AL, Amod A, Mankovsky B, Desouza C, Gorgojo-Martinez JJ, Arechavaleta R, Tu ST, Buse JB, SOUL Study Group* .   +22 more
europepmc   +1 more source

The unique cognitive phenotype of ASD + ADHD co-occurrence: evidence for planning and attention deficits as a differentiating approach. [PDF]

Front Pediatr
Wang T, Bai M, Zhang Z, Jia F.
europepmc   +1 more source