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Results 71 to 80 of about 8,611,868 (262)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source

, 2017
The aim of this study was to evaluate the efficacy of using appropriate biomarkers of inflammation for diagnosis of tuberculosis in children, monitoring the disease and the effects of the applied therapy.Material and methods: In this study, 60 ...
ÐœÐ¸Ñ€Ñ‡ÐµÐ²ÑÐºÐ° (Mirchevska), Ð’Ð¸Ð¾Ð»ÐµÑ‚Ð° (Violeta)
core +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

Adiponectin and Leptin—Considerations in Adult Patients with Spinal Muscular Atrophy Type 3

Diagnostics
Background: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of alpha motor neurons in the spinal cord, leading to progressive proximal muscle weakness and paralysis.
Marija Miletić +7 more
doaj +1 more source

To $${d}$$ d , or not to $${d}$$ d : recent developments and comparisons of regularization schemes

European Physical Journal C: Particles and Fields, 2017
We give an introduction to several regularization schemes that deal with ultraviolet and infrared singularities appearing in higher-order computations in quantum field theories.
C. Gnendiger +18 more
doaj +1 more source

Ð¢Ñ€Ð¸ ÑÐ»ÑƒÑ‡Ð°Ð¸ Ð½Ð° Syndroma Willi Prader Labhardt Ð²Ð¾ Ð´Ð¾ÐµÐ½ÐµÑ‡ÐºÐ° Ð²Ð¾Ð·Ñ€Ð°ÑÑ‚ [PDF]

, 2017
Authors presented three cases of Willi Prader Labhardt Syndroma whose cardinal symptoms are: psychomotor retardation, proportional obesity, hypogenitalism, a small bifrontal circumference, and carp-like mouth.During the pregnancy, children's mothers felt
Ð¡Ð¿Ð¸Ñ€Ð¾Ð²ÑÐºÐ¸, Ð—Ð¾Ñ€Ð°Ð½ +2 more
core +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

, 2017
The aim of this study was to determinate the importance of 6MWT in children diagnosed with neuromuscular diseases. We evaluated the distances walked and the level of fatigue manifested.
Sabolik, Vesna +8 more
core +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source

astrophysics
b physics
7. clean energy

hadron-hadron scattering experiments