Results 261 to 270 of about 5,871,901 (302)

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Vitamin D and calcium-phosphorus in serum of children with celiac disease in a zone of high sunlight exposure. [PDF]

Front Pediatr
Kamilova AT, Alieva NR, Akhmedova DI, Abrorova BT.   +3 more
europepmc   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Cerebral glucose delivery, transport and metabolism: Theory and modeling using four, three, and two tissue compartments. [PDF]

J Cereb Blood Flow Metab
Seidemo A, Knutsson L, Yadav NN, Sundgren PC, Wirestam R, van Zijl PC.   +5 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching. [PDF]

Nat Commun
Würtz M, Tonon G, Vermeulen BJA, Zezlina M, Gao Q, Neuner A, Seidl A, König M, Harkenthal M, Eustermann S, Erhardt S, Lolicato F, Schiebel E, Pfeffer S.   +13 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Correction: Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling. [PDF]

Acta Neuropathol Commun
Okonechnikov K, Ghasemi DR, Schrimpf D, Tonn S, Mynarek M, Koster J, Milde T, Zheng T, Sievers P, Sahm F, Jones DTW, Deimling AV, Pfister SM, Kool M, Pajtler KW, Korshunov A.   +15 more
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Preschoolers in severely food insecure Guatemalan Mayan households consume a monotonous grain-based diet. [PDF]

BMC Public Health
Monroy-Valle M, Estrada MR, Del Carmen Caamaño M, Cordón-Arrivillaga K, Lane G, Vatanparast H.   +5 more
europepmc   +1 more source