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occumb: An R package for site occupancy modeling of eDNA metabarcoding data

Population Ecology, EarlyView.
This study introduces a new R package, occumb, for the convenient application of site occupancy modeling using environmental DNA (eDNA) metabarcoding data. We outline a data analysis workflow, including data setup, model fitting, model assessment, and comparison of potential study settings based on model predictions, all of which can be performed using
Keiichi Fukaya, Yuta Hasebe
wiley +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source

ÐŸÐ Ð˜Ð¡Ð¢ÐÐŸ Ð”Ðž Ð‘Ð•Ð—Ð‘Ð•Ð”ÐÐ Ð’ÐžÐ”Ð Ð—Ð ÐŸÐ˜Ð•ÐŠÐ• Ð’Ðž Ð¡Ð•Ð’Ð•Ð ÐžÐ˜Ð¡Ð¢ÐžÐ§ÐÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ ÐÐ Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ- Ð Ð•Ð¢Ð ÐžÐ¡ÐŸÐ•ÐšÐ¢Ð˜Ð’ÐÐ ÐÐÐÐ›Ð˜Ð—Ð [PDF]

Clostridium difficile Strains Associated with Nosocomial Infections - Laboratory Diagnosis, Prevalence, Susceptibility and Molecular Characterization of the Isolates [PDF]

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source

, 2017
International Agency for Research on Cancer (IARC) in 2009 classified all forms of asbestos as sure human carcinogen (Group 1) for lung cancer, mesothelioma of the pleura, and cancer of the larynx and ovary.
Ð Ð¸ÑÑ‚Ð¾Ð²ÑÐºÐ° (Ristovska), Ð“Ð¾Ñ€Ð´Ð°Ð½Ð° (Gordana) +2 more
core +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source

, 2017
Laboratory acquired infections (LAI) are all infections obtained during laboratory work, divided into several types, according to the manner of occurrence.
Kakaraskoska Boceska (ÐšÐ°ÐºÐ°Ñ€Ð°ÑÐºÐ¾ÑÐºÐ° Ð‘Ð¾Ñ†ÐµÑÐºÐ°), Biljana (Ð‘Ð¸Ñ™Ð°Ð½Ð°)
core +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source

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