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RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source

Measurement of D0, D+, D*+ and D s + production in Pb-Pb collisions at s N N = 5.02 $$ \sqrt{{\mathrm{s}}_{\mathrm{NN}}}=5.02 $$ TeV

Journal of High Energy Physics, 2018
We report measurements of the production of prompt D0, D+, D*+ and D s + mesons in Pb–Pb collisions at the centre-of-mass energy per nucleon-nucleon pair s N N = 5.02 $$ \sqrt{s_{\mathrm{NN}}}=5.02 $$ TeV, in the centrality classes 0–10%, 30–50% and 60 ...
The ALICE collaboration +1003 more
doaj +1 more source

Ob etimologii i semantike termina voršud/vožšud [On the Etymology and Semantics of the Term voršud/vožšud]; pp. 276-282 [PDF]

Linguistica Uralica, 2014
The paper deals with the concept of Ð²Ð¾ÑÑÑÐ´/Ð²Ð¾Ð¶ÑÑÐ´ in the Udmurt language, which used to serve as a theonym for one of the traditional deities. The word was preserved by Udmurt local groups living in a foreign-language environment.
Nadežda Šutova
doaj +1 more source

, 2018
Non-communicable diseases, also known as modern-life diseases, are the leading cause of morbidity and mortality in the world and in the Republic of Macedonia. The complexity of their occurrence, often associated with multifactorial etiology and lifestyle
Ð¡Ð¿Ð°ÑÐ¾Ð²ÑÐºÐ¸ (Spasovski), ÐœÐ¾Ð¼Ðµ (Mome) +3 more
core +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts +2 more
wiley +1 more source

ÐÐÐ¢Ð˜ÐœÐ˜ÐšÐ ÐžÐ‘ÐÐ Ð Ð•Ð—Ð˜Ð¡Ð¢Ð•ÐÐ¦Ð˜ÐˆÐ (ÐÐœÐ ) Ð’Ðž Ð•Ð’Ð ÐžÐŸÐ Ð˜ Ð‘ÐÐ›ÐšÐÐÐ¡ÐšÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ – ÐŸÐ Ð•Ð“Ð›Ð•Ð” ÐÐ Ð¡Ð•Ð“ÐÐ¨ÐÐÐ¢Ð Ð¡ÐžÐ¡Ð¢ÐžÐˆÐ‘Ð [PDF]

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source

ÐŸÐ Ð˜Ð¡Ð¢ÐÐŸ Ð”Ðž Ð‘Ð•Ð—Ð‘Ð•Ð”ÐÐ Ð’ÐžÐ”Ð Ð—Ð ÐŸÐ˜Ð•ÐŠÐ• Ð’Ðž Ð¡Ð•Ð’Ð•Ð ÐžÐ˜Ð¡Ð¢ÐžÐ§ÐÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ ÐÐ Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ- Ð Ð•Ð¢Ð ÐžÐ¡ÐŸÐ•ÐšÐ¢Ð˜Ð’ÐÐ ÐÐÐÐ›Ð˜Ð—Ð [PDF]

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source

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