Results 121 to 130 of about 8,213,460 (300)

High-risk newborns and pervasive developmental disorders [PDF]

open access: yes, 2017
Aim of the paper: Analysis of developmental abilities in high-risk infants, with an emphasis on risk, early screening and early diagnosis of disorders of the autistic spectrum (ASD).
Dukovska, Valentina   +3 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Perturbations in $$\textbf{O}(D,D)$$ O ( D , D ) string cosmology from double field theory

open access: yesEuropean Physical Journal C: Particles and Fields
The low-energy limit of string theory contains additional gravitational degrees of freedom, a skew-symmetric tensor B-field and a scalar dilaton, that are not present in general relativity.
Stephen Angus, Shinji Mukohyama
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Report on the interim results of the expert and analytical event Monitoring and spot checks of the conditions and volumes of placement by the State Corporation Deposit Insurance Agency of federal loan bonds in subordinated bank loans and (or) payment o [PDF]

open access: yes, 2015
Original title in Russian is Отчет о промежуточных результатах ÑкÑпертно”аналитичеÑкоÐóо мероприÑÑ‚Ð¸Ñ «ÐœÐ¾Ð½Ð¸Ñ‚оринÐó и выборочные проверки уÑловий и оР...
Russian Federation: Accounts Chamber of the Russian Federation
core  

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

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