Results 61 to 70 of about 121 (121)
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia
Advanced Science, EarlyView.A continuous, multi‐domain characterization of cognitive decline across the Alzheimer's disease spectrum identifies when individual cognitive measures become abnormal. Episodic memory declines first, followed by executive function, language, processing speed, and visuospatial abilities, supporting improved clinical interpretation and optimized endpoint
Fredrik Öhman +3 more
wiley +1 more source
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Advanced Science, EarlyView.Photonic time crystals (PTCs) are systems in which electromagnetic parameters are modulated periodically in time, producing momentum bandgaps via temporal scattering rather than spatial Bragg processes. This review examines the theoretical frameworks, modeling, and computational tools for time‐varying media, and summarizes experimental demonstrations ...
Ranjan Kumar Patel +3 more
wiley +1 more source
Advanced Science, EarlyView.The formation of insulating Li2S during discharge in solid‐state lithium–sulfur batteries passivate reaction sites and limits sulfur utilization. In this work, a microstructure‐resolved modeling framework coupling transport and reaction kinetics is developed to predict charge–discharge behavior and reveal particle‐scale species evolution and incomplete
Arpan K. Sharma +4 more
wiley +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Hierarchical Artificial Muscle with Nonlinear Elasticity for Antagonistic and Cyclic Robotics
Advanced Science, EarlyView.We construct hierarchical muscles by plying nylon fibers around a heating wire. The hierarchical muscle shows a J‐shaped passive curve, which shows benefit in antagonistic muscle pair and work accumulation mechanism. We also develop a computational, first‐principle model to understand the physics of both active actuation stroke and passive J‐curve ...
Samuel Tsai +15 more
wiley +1 more source
Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond
Advanced Science, EarlyView.Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi +4 more
wiley +1 more source
Advanced Science, EarlyView.This review examines the evolution of bioprinting toward minimally invasive in situ strategies for internal organ regeneration. It defines the technological roadmap from handheld systems to advanced minimally invasive bioprinting platforms, positioning soft robotics as a core enabler.
Duc Tu Vu +9 more
wiley +1 more source
On the Ordering Mechanism of Cu+ in 2D van der Waals Multiferroic CuCrP2S6
Advanced Science, EarlyView.Temperature‐dependent X‐ray single‐crystal diffuse scattering measurements of CuCrP2S6 in the (H, K, 0) plane reveal the gradual emergence and strengthening of short‐range order upon cooling from 230 to 170 K. At intermediate temperatures, diffuse features become pronounced and eventually lock into sharp incommensurate satellite reflections, indicating
Jiasen Guo +5 more
wiley +1 more source