FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
МЕЖБЮДЖЕТ�ЫЕ ОТ�ОШЕ�ИЯ И ОС�ОВ�ЫЕ ��ПР�ВЛЕ�ИЯ ИХ СОВЕРШЕ�СТВОВ��ИЯ (�� ПРИМЕРЕ ГРУЗИИ) [PDF]
, 2017 The paper considers inter-budgetary relations as one of the most complex and ambiguous spheres of functioning of state institutions of Georgia. The aim is to identify the problematic aspects of Georgia's budget policy and formulate the key directions for
Abuselidze, George
core +3 more sources
ИÑпитување на кинетиката на радиоактивно обележен кортизол кај Ñтаорци [PDF]
, 2016 Kinetics of tritium labeled coгtisol was performed in control rats, rats treated with Synacthen Depot and rats treated with Dexamethason i.m. Rats were injected with 2 microCuri directly into the lateral tail vein and timed samples were collected by ...
СпироÑки (Spiroski), Мирко (Mirko) +2 more
core +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
ЛабораториÑки Ñтекнати инфекции кај вработените во микробиолошките лаборатории во Република Македонија [PDF]
, 2017 Laboratory acquired infections (LAI) are all infections obtained during laboratory work, divided into several types, according to the manner of occurrence.
Kakaraskoska Boceska (КакараÑкоÑка БоцеÑка), Biljana (Биљана)
core +1 more source
Structure of Patients Treated in Intensive Coronary Care Unit on Department for Internal Medicine – PHO General Hospital Kumanovo – in the Period from 2009-2013 Year [PDF]
, 2015 ОСÐОВÐ: Главната функција на коронарната единица е доÑтапноÑÑ‚ на телеметрија или континуирано Ñледење на Ñрцевиот ритам и крвниот притиÑок пр
Anchevski, Tomica
core +2 more sources
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
FEBS Letters, EarlyView.Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source