Results 11 to 20 of about 148 (147)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Detecting rs‐fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Preserved resting‐state functional MRI (rs‐fMRI) networks are typically observed in Disorders of Consciousness (DOC). Despite the widespread use of rs‐fMRI in DOC, a systematic assessment of networks is needed to improve the interpretability of data in clinical practice.
Jean Paul Medina Carrion, Mario Stanziano, Ludovico D'Incerti, Davide Sattin, Stefania Ferraro, Davide Rossi Sebastiano, Francesca Giulia Magnani, Alice Deruti, Davide Fedeli, Ludovico Minati, Francesca Epifani, Marina Grisoli, Matilde Leonardi, Maria Grazia Bruzzone, Anna Nigri, Cristina Rosazza   +15 more
wiley   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Anomaly Detection Method for Hybrid Workpieces Using Dynamic Time Warping

Advanced Engineering Materials, EarlyView.
Monitoring of hybrid workpieces: when machining hybrid workpieces, unavoidable axial deviations of the material transition zone cause temporal shifts in the process force signals. A new anomaly detection method based on dynamic time warping is proposed to detect material defects.
Berend Denkena, Benjamin Bergmann, Heinrich Klemme, Miriam Handrup   +3 more
wiley   +1 more source

Dimensionless Investigations on Energy Conversion and Analysis of Interlayer Time in Laser‐Based Powder Bed Fusion of Polymers for Polyamide 12 with Nanoadditives and Polypropylene

Advanced Engineering Materials, EarlyView.
This study explores the energy conversion in powder bed fusion of polymers using laser beam for polyamide 12 and polypropylene powders. It combines material and process data, using dimensionless parameters and numerical models, to enable the prediction of suitable printing parameters.
Christian Schlör, Moritz Grünewald, Kevin Popp, Ihsan Murat Kusoglu, Stephan Barcikowski, Stan Gann, Thomas Schuffenhauer, Martin Bastian, Claas Bierwisch, Johannes Rudloff   +9 more
wiley   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Mechanical and Microstructural Effects of ZrO2 Nanoparticles in Fe20Cr Oxide Dispersion‐Strengthened Alloys Processed by Laser Powder Bed Fusion

Advanced Engineering Materials, EarlyView.
The influence of oxide nanoparticle synthesis route and concentration on microstructure and high‐temperature performance of additively manufactured oxide dispersion‐strengthened steels is investigated. Comparing laser‐generated and chemically synthesized ZrO2 nanoparticles, the study reveals how dispersion quality, crystal structure and particle size ...
Mareen Goßling, Silja‐Katharina Rittinghaus, Felix Radtke, Abdelrahman Elsayed, Marina Macias Barrientos, Ulf Ziesing, Louis Becker, Ihsan Murat Kuşoğlu, Christoph Broeckmann, Ulrich Krupp, Avinash Hariharan, Sebastian Weber, Bilal Gökce   +12 more
wiley   +1 more source

Thermally Induced Gelling Systems Based on Patchy Polymeric Micelles

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
A novel strategy to design thermally induced gelling systems with tunable material properties is reported. Polymeric mixed‐shell micelles displaying multiple thermosensitive patchy domains formed hydrogels by assembling into well‐entangled worm‐like network structures upon heating to body temperature. The patchy micelle design significantly affects the
Binru Han, Shota Fujii, André J. van der Vlies, Masoud Ghasemi, Joshua T. Del Mundo, Sarah N. Kiemle, Esther W. Gomez, Enrique D. Gomez, Ralph H. Colby, Urara Hasegawa   +9 more
wiley   +1 more source