Results 101 to 110 of about 6,172,850 (251)

Ðндроид/нозе и нозе/труп индекÑи одредени Ñо абÑорпциметрија Ñо двојно-енергетÑки x-зраци кај Кушинг и не-Кушинг здебелени жени [PDF]

, 2018
The aim of this study was to evaluate the central obesity, which is a main characteristic of Cushing's syndrome (CS), with dual-energy x-ray absorptiometry (DXA) and to determine DXA indexes that precisely differentiate CS from non CS obese women.
ТодоровÑка (Todorovska), Лидија (Lidija), ШубеÑка-Стратрова (Shubeska Stratrova), Славица (Slavica)   +1 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

ИСХРÐÐÐТРИ ЈÐÐ’ÐОТО ЗДРÐВЈЕ – СОСТОЈБÐ, ПОЛИТИКИ И ПРЕДИЗВИЦИ [PDF]

, 2017
Студијата  Ð·Ð° глобалното оптоварување Ñо болеÑтите од 2013 година покажа дека факторите на ризик поврзани Ñо иÑхраната Ñе доминантни во Ð½Ð°Ñ ...
СпироÑки, Игор
core   +1 more source

From simple symptoms to complex diagnosis

, 2020
Педиатр зачастую является первым доктором, сталкивающимся с началом различных, в том числе редких заболеваний.
Elena V. Striga, Evelina E. Lokshina, Evgeniia M. Tolstova, Marina V. Besedina, Nadezhda S. Zaytseva, null null, null null, null null, null null, null null, null null, null null, Olga V. Zaytseva, Tatiana Iu. Beliaeva   +13 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Segmentation of Natural Images Using Scale-Space Representation with Multi-Scale Edge Supervised Hierarchical Linking [PDF]

, 2006
In general purpose computer vision systems, non-supervised image analysis is mandatory in order to achieve an automatic operation. In this paper a different approach to image segmentation for natural scenes is presented.
Divorra Escoda, O., Vandergheynst, P.
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source