Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
ÐÐТИМИКРОБÐРРЕЗИСТЕÐЦИЈР(ÐМР) ВО ЕВРОПРИ БÐЛКÐÐСКИОТ РЕГИОР– ПРЕГЛЕД ÐРСЕГÐШÐÐТРСОСТОЈБР[PDF]
Ðнтимикробната резиÑтенција (ÐМР) претÑтавува глобален проблем, чијшто размер е оÑобено загрижувачки во оние земји каде што не поÑтојат довол
ХриÑтова, КриÑтина+6 more
core +1 more source
Epilepsy - Treatment with Ðcupuncture: Case Ð eport [PDF]
ЦЕЛ: Целта на овој труд е да Ñе прикаже Ñлучај Ñо епилепÑија, ÑоÑтојбата пред и поÑле третманот Ñо акупунктура и ефектите на акупунктурниот трет
ÐÑ€ÑовÑка (Arsovska), Благица (Blagica)+2 more
core +2 more sources
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa+8 more
wiley +1 more source
Е-кадеринот и неговата улога кај пациентки Ñо Ñерозен оваријален карцином во напреднат Ñтадиум [PDF]
Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ÐлулоÑки, Игор
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In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
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Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
БезбедноÑта во Ñообраќајот на патиштата – предизвици за јавноздравÑтвен одговор [PDF]
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Тозија (Tozija), Фимка (Fimka)
core +1 more source
Techniques and Methods for Detection and Diagnosis of Oral Premalignant and Malignant Lesions [PDF]
ОСÐОВÐ: Оралните премалигни и малигни лезии бележат тенденција на доцна детекција, која е на штета на пациентите поради виÑоките Ñтапки нР...
Minovska, Ana+4 more
core +2 more sources
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang+2 more
wiley +1 more source