Results 31 to 40 of about 5,652,960 (255)

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

ÐÐТИМИКРОБÐРРЕЗИСТЕÐЦИЈР(ÐМР) ВО ЕВРОПРИ БÐЛКÐÐСКИОТ РЕГИОР– ПРЕГЛЕД ÐРСЕГÐШÐÐТРСОСТОЈБР[PDF]

open access: yes, 2017
Ðнтимикробната резиÑтенција (ÐМР) претÑтавува глобален проблем, чијшто размер е оÑобено загрижувачки во оние земји каде што не поÑтојат довол
ХриÑтова, КриÑтина   +6 more
core   +1 more source

Epilepsy - Treatment with Ðcupuncture: Case Рeport [PDF]

open access: yes, 2016
ЦЕЛ: Целта на овој труд е да Ñе прикаже Ñлучај Ñо епилепÑија, ÑоÑтојбата пред и поÑле третманот Ñо акупунктура и ефектите на акупунктурниот трет
ÐÑ€ÑовÑка (Arsovska), Благица (Blagica)   +2 more
core   +2 more sources

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

Е-кадеринот и неговата улога кај пациентки Ñо Ñерозен оваријален карцином во напреднат Ñтадиум [PDF]

open access: yes, 2017
Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ÐлулоÑки, Игор
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

БезбедноÑта во Ñообраќајот на патиштата – предизвици за јавноздравÑтвен одговор [PDF]

open access: yes, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Тозија (Tozija), Фимка (Fimka)
core   +1 more source

Techniques and Methods for Detection and Diagnosis of Oral Premalignant and Malignant Lesions [PDF]

open access: yes, 2015
ОСÐОВÐ: Оралните премалигни и малигни лезии бележат тенденција на доцна детекција, која е на штета на пациентите поради виÑоките Ñтапки нР...
Minovska, Ana   +4 more
core   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

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