Results 61 to 70 of about 8,825,592 (258)
Adiponectin and Leptin—Considerations in Adult Patients with Spinal Muscular Atrophy Type 3
DiagnosticsBackground: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of alpha motor neurons in the spinal cord, leading to progressive proximal muscle weakness and paralysis.
Marija Miletić +7 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2017 Intensification of systemic chemotherapy with in- clusion of high doses methotrexate (MTX) has contributed to the improvement of event-free survival in children with acute lymphoblastic leukemia (ALL). Despite this benefit, this agent might cause serious
ЕфтимијадоÑка (Eftimijadoska), Фани (Fani)
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2017 The study aims to compare the conventional open technique for treating inguinal hernia versus laparoscopic assisted technique of percutaneous closure of the internal inguinal ring in female children with clinically diagnosed indirect inguinal hernia ...
Симеонов (Simeonov), РиÑто (Risto) +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2018 The aim of this study was to evaluate the central obesity, which is a main characteristic of Cushing's syndrome (CS), with dual-energy x-ray absorptiometry (DXA) and to determine DXA indexes that precisely differentiate CS from non CS obese women.
ШубеÑка-Стратрова (Shubeska Stratrova), Славица (Slavica) +1 more
core
European Physical Journal C: Particles and FieldsThis study investigates the three-body decay process $$B^{+} \rightarrow D^{*+} D^{-} K^{+}$$ B + → D ∗ + D - K + , aiming to explore the possible origins of $$T^{*}_{\bar{c}\bar{s}0}(2870)^0$$ T c ¯ s ¯ 0 ∗ ( 2870 ) 0 and $$\chi _{c1}(3872)$$ χ c 1 ...
Zuo-Ming Ding, Qi Huang, Jun He
doaj +1 more source
Journal of Applied Studies in Language, 2019 This study aims to investigate the pronunciation mistakes in English in accordance with the phonetic study of voiceless and voiced inter- dental fricatives [θ], [ð] and alveolar liquid [r] sounds among Chinese learners of English at University Utara ...
Mizanur Rahman, Dr. Md. Kamrul Hasan
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source