Results 231 to 240 of about 6,308,828 (253)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The effect of centralized care on the management of postoperative fluctuations in plasma sodium concentration after pediatric suprasellar brain tumor surgery. [PDF]

Pituitary
Hulsmann SC, Zaal DC, van Gestel JPJ, Sie M, Rooda OHJE, van Baarsen KM, Musson REA, Bakker B, Nieuwenhuis EES, Hoving EW, Asperen RMW, van Santen HM.   +11 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Vitamin D and Disease Perception Outcomes in a Cluster of Patients with High-Disease-Activity Chronic Spontaneous Urticaria. [PDF]

J Clin Med
Lekli E, Hoxha M, Bova M, Shkëmbi D, Ndreu E, Hajrulla X, Petrela E, Qirko E.   +7 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Microwave-Responsive MnFe-Based Molybdenum Disulfide Nanoflowers for Enhanced Thermal-Dynamic-Chemo Synergistic Therapy in Bladder Cancer. [PDF]

Int J Nanomedicine
Liu Y, Chen Y, Ye S, Hu J, Zheng Z, Lu K, Chen W, Yan Z, Li X.   +8 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Effects of vitamin D supplementation combined with resistance exercise on body composition and metabolic variables in older women: a randomized clinical trial. [PDF]

Clinics (Sao Paulo)
Queiroz IPDS, Alonso AC, da Silva VC, Machado-Lima A, Pipa PLAB, Soares-Junior JM, Baracat EC, Greve JMD, Bastos MF, Brech GC.   +9 more
europepmc   +1 more source

Vitamin D Deficiency in Institutionalized Older Adults: Associations with Supplementation Practices but Not with Cognitive Decline or Dementia. [PDF]

Nutrients
Soares LD, Teixeira Rosales M, Silveira BC, Rizzolli AM, Mazala CHSG, Lemes IT, Sinnott FDSS, Santana TF, Espinosa ÉP, Drawanz EN, Araújo ABG, Moura NP, Longoni A, Souza DO, Rodrigues MNM, De Assis AM.   +15 more
europepmc   +1 more source