Results 61 to 70 of about 2,864 (108)

Hollow Cholesteric Liquid Crystal Elastomer Fiber with Synergistically Enhanced Resilience and Mechanochromic Sensitivity

Advanced Science, EarlyView.
It describes hollow cholesteric liquid crystal elastomer fiber with radial helix prepared by solvent evaporation‐induced assembly and template assistance. The fiber show mechanochromic wavelength blueshift of 2.25 nm·%−1 under low strain. Excellent mechanochromic reversibility and resilience are devoted by cross‐linking in the wall layer.
Wenwen Wang, Weijie Cheng, Feixia Liu, Kangyu Jia, Huihui Zhan, Chenguang Yang, Ke Liu, Qiongzhen Liu, Dong Wang   +8 more
wiley   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source

Subgenome Partitioning and Polyploid Genome Evolution in the Loach Family Botiidae (Order Cypriniformes)

Advanced Science, EarlyView.
This study investigates subgenome evolution and polyploidy in Cypriniformes fish, revealing complex phylogenetic relationships and genomic dynamics. By applying advanced subgenome partitioning methods, it uncovers novel insights into transposon activity and gene fractionation.
Yunyun Lv, Jia Li, Yanping Li, Yu Huang, Qiang Lai, Zhengyong Wen, Jun Wang, Yang He, Jinrong Shi, Zejin Huang, Ying Jiang, Yves Van de Peer, Qiong Shi, Biwen Xie, Yongming Wang   +14 more
wiley   +1 more source

Rapid‐Turnaround Co‐Administration of mRNA‐Based MHC‐I and MHC‐II‐Restricted Neoantigens Enhances Immune Responses of Antigen‐Specific CD8+ T Cells and Anti‐Cancer Efficacy in Colorectal Cancer

Advanced Science, EarlyView.
Co‐administration with MHC class I‐ and II‐restricted neoantigens encoding mRNA‐based personalized cancer vaccines in a mouse CRC model can induce antigen‐specific immune responses and anti‐cancer effects. Notably, vaccination at an early stage of cancer development can have potent anti‐cancer effects. Furthermore, combining mRNA with immune checkpoint
Seongje Cho, Woori Kwak, Hyunho Yoon, Jisun Lee, Seonghyun Lee, Hyo‐Jung Park, Sohee Jo, Yu‐Sun Lee, Yu‐Jeong Seo, Youngran Cho, Seo‐Hyeon Bae, Subin Yoon, Gahyun Roh, Dahyeon Ha, Ayoung Oh, Eun‐Jin Choi, Soo‐Yeon Lee, Huijeong Choi, Jungmin Kim, Yeeun Lee, Sowon Lee, Sang‐In Park, Dae‐Keun Kim, Jun Chang, Ki Tae Kim, Kwoneel Kim, Jae‐Hwan Nam   +26 more
wiley   +1 more source

Real‐Time Tracking of ASCT2‐Mediated Glutamine Uptake in Living Tumors With a Bioorthogonal Bioluminescent Probe

Advanced Science, EarlyView.
A bioluminescent probe, BLGLN, comprising BL568 and ASCT2‐uptaken AA201, enables real‐time monitoring and evaluation of ASCT2‐mediated glutamine uptake rates in living tumors via Staudinger ligation, aiding tumor metabolism studies and targeted therapeutics.
Bing‐Jun Zhou, Ji‐Lei Zhao, Fan Yin, Wen‐Da Chen, Yi Sun, Ying‐Ying Ren, Yi‐Min Chen, Tian Xie, Chong Duan, Jian‐Liang Zhou   +9 more
wiley   +1 more source

A Lipid with Lewis Pair‐Mediated Targeting and Multiple Stimuli‐Responsive Delivery of Antibiotics for Bacterial Infections

Advanced Science, EarlyView.
Lewis pair‐integrated lipids (Lp‐lipids), combining targeted delivery and stimuli‐responsive are developed for antibiotic delivery. These lipids form nanoparticles that bind biofilms via boronate ester bonds and respond to acidic pH, H2O2, and ATP, enabling controlled drug release.
Xiaojian Yan, Lei Hua, Hongping Wan, Yong Liu, Tao Jin, Yicen Ge, Michael R Hamblin, Mahdi Karimi, Xinghong Zhao, Yan Hu, Linqi Shi, Yuanfeng Li   +11 more
wiley   +1 more source

Dual‐Wavelength Responsive Hydrogel Glue with Visible‐Light Bonding and UV‐Triggered Debonding via Ortho‐Nitrobenzyl Cleavage

Advanced Science, EarlyView.
A dual‐wavelength responsive hydrogel glue achieves orthogonal control of bonding and debonding: visible light drives crosslinking via acrylic acid, while ortho‐nitrobenzyl (ONB) units enable rapid UV‐triggered network cleavage. This smart adhesive offers strong adhesion, fast on‐demand debonding, and spatiotemporal precision for potential applications
Huaming Wang, Xianyan Shen, Changling Du, Xian‐You Liu, Anyu Yang, Yanni Cao, Aijie Han, Qihan Liu, Jennifer Laaser, Wei Zhang   +9 more
wiley   +1 more source

Unveiling Exciton‐Plasmon Polariton Coupling Regions via Polarization‐Enhanced Optical Nanoscopy

Advanced Science, EarlyView.
Polarization‐enhanced single‐molecule localization microscopy, utilizing a liquid crystal variable retarder (LCVR), actively controls the on‐off intensity modulation of fluorophores. This active intensity modulation improves the localization accuracy of the point spread function (PSF), enabling high‐contrast super‐resolution imaging with significantly ...
Bin Chan Joo, Dong Hee Park, Kyu Ri Choi, Yeon Ui Lee   +3 more
wiley   +1 more source

Heme/NADH Mimics Co‐Decorated Allosteric Capsules for Regulating Oxygen Activation and Upregulating Intracellular Methionine Depletion

Advanced Science, EarlyView.
Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma, Yihao Zhang, Junkai Cai, Baotong Ding, Yang Jiao, Chunying Duan   +5 more
wiley   +1 more source

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source