Results 181 to 190 of about 5,652,415 (208)

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Identifying lifelong factors that impact brain health and functional outcomes in adults with childhood-onset type 1 diabetes: the cognition and longitudinal assessments of risk factors over 30 years (CLARiFY) - diabetes complications study protocol. [PDF]

BMJ Open
Brown A, Sakowski SA, Moran C, Koubek EJ, Srikanth VK, Zhao L, Collyer T, Adamson CL, Northam EA, Beare R, Cameron FJ, Feldman EL.   +11 more
europepmc   +1 more source

Advantages and limitations of navigation‐based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard, Simon J. P. Meara, Ehab M. Ibrahim, Carl G. Rowbottom   +3 more
wiley   +1 more source

Revisiting D-Acylases for D-Amino Acid Production. [PDF]

Microb Biotechnol
Martínez-Rodríguez S, Gavira JA.
europepmc   +1 more source

Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents. [PDF]

PLoS One
Nourmandipour F, Emadi R, Salehi P, Zarin MKZ, Khoramjouy M, Beirami AD, Faizi M.   +6 more
europepmc   +1 more source

The efficacy of calcium and vitamin D3 supplementation in improving pregnancy and neonatal outcomes. [PDF]

Front Pediatr
Wang F, Shen M, Wu T, Zhang Y, Wang Y, Zhou C.   +5 more
europepmc   +1 more source

Effect of vitamin D supplementation on glycemic control, insulin sensitivity, and pregnancy outcomes in gestational diabetes patients undergoing dietary therapy. [PDF]

J Health Popul Nutr
Yu S, Yu X, Li F.
europepmc   +1 more source