Results 81 to 90 of about 92 (92)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, Volume 293, Issue 9, Page 2673-2691, May 2026.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Why Can't I Figure This Out? Identity Negotiation and Higher Education Decision Making Among Women With Caring Responsibilities

Gender, Work &Organization, Volume 33, Issue 3, Page 947-959, May 2026.
ABSTRACT Women with unpaid caring responsibilities frequently wrestle with challenges when making decisions about higher education study, asking “Why can't I figure this out?” Statistics have persistently demonstrated that women undertake the majority of unpaid care work, however, unpaid carers are an underrepresented cohort in research, in higher ...
Deborah Munro, Jill Willis, Andrew Gibson, Melinda Laundon   +3 more
wiley   +1 more source

Dental Caries Prevalence Among Dubai and Northern Emirates Public Schoolchildren: An Epidemiological Retrospective Study (2015–2019)

International Journal of Paediatric Dentistry, Volume 36, Issue 3, Page 477-492, May 2026.
ABSTRACT Background Oral health is a key public health priority in the United Arab Emirates (UAE), yet the effectiveness of the existing programmes is unclear due to limited standardised data. Aim To estimate schoolchildren caries prevalence across UAE over five academic years (2015–2019) and assess the associated factors.
Khawla Humaid Belhoul Alfalasi, Tom Loney, Momen Atieh, Christopher Cardwell, Haifa Hannawi, Maimouneh Qazi, Gerry McKenna   +6 more
wiley   +1 more source

Fully Tunable Phosphorylation of RPS6A Ensures the Successful Development of Arabidopsis Seedlings

Plant, Cell &Environment, Volume 49, Issue 5, Page 2783-2794, May 2026.
ABSTRACT Light enhances protein translation, enabling young seedlings to rapidly and timely acquire photosynthetic capacities. Sequential phosphorylation of ribosomal protein S6 (RPS6) was implicated in the light‐enhanced translation; however, the exact phosphorylation sites and the biological relevance of RPS6 multi‐phosphorylation in seedling ...
Yueh Cho, Guan‐Hong Chen, Shu‐Hsing Wu   +2 more
wiley   +1 more source

Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade, Tales Alexandre Costa‐Silva, Gisele Monteiro   +2 more
wiley   +1 more source

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

Discovery of [1,2,4]triazolo[1,5‐a]pyrimidine‐Imatinib Hybrids With Selective Cytotoxic Activity: A Mechanistically Divergent Series From Direct BCR‐ABL1 Inhibition

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Discovery of imatinib–triazolopyrimidine hybrids with selective cytotoxicity and a mechanism distinct from classical BCR‐ABL1 inhibition. This bioisosteric strategy introduces a novel compounds, paving the way for innovative antileukemic therapies with differentiated profiles.
Stefany Castro Bazan Moura, Andressa Paula de Oliveira, Joao de Mello Rezende Neto, Rafael Ferreira Dantas, Floriano Paes Silva‐Jr, Luiz Claudio Pimentel, Mayara Salles do Nascimento Carvalho, Debora Inacio Leite, Daiane Vitoria da Silva, Monica Macedo Bastos, Nubia Boechat   +10 more
wiley   +1 more source

Ultrathin Perovskite Solar Cells With γ‐Ray Tolerance Enabled by a Flexible Radiation‐Resistant Plastic Substrate

Solar RRL, Volume 10, Issue 8, 27 April 2026.
This work demonstrates ultrathin, flexible perovskite solar cells exhibiting exceptional gamma‐ray radiation tolerance. By integrating a radiation‐tolerant perovskite solar cell with an ultrathin parylene/SU‐8 plastic substrate, the cells maintain power conversion efficiencies of 15.0% after severe total ionizing dose conditions up to 890 krad (Si ...
Hiroaki Jinno, Tomoyuki Yokota, Dou Zhao, Daisuke Kobayashi, Takahiro Makino, Akinori Takeyama   +5 more
wiley   +1 more source

3D‐Printed Geopolymer as a Basic Heterogeneous Catalyst for the Synthesis of α‐Cyanoacrylates Through the Knoevenagel Condensation

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
3D‐printed geopolymers are presented as efficient and reusable heterogeneous catalysts for the Knoevenagel condensation. Under mild and green conditions, they promote the high‐yield synthesis of diverse α‐cyanoacrylates with remarkable stability and scalability.
Francesca T. Albino, Pedro A. M. Moro, Wanessa B. Menegaro, Luciano Senff, Marcus M. Sá, Dachamir Hotza   +5 more
wiley   +1 more source

β‐Mannosyl Triazoles as Mimics of Galactosyl Galectin‐3 and Galectin‐9 N‐Terminal Domain Inhibitors

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Galacto‐mimicking mannosyl monotriazoles, but not bis‐triazoles, inhibit galectin‐3 and galectin‐9 N‐terminal domain. Mannosyl β‐C‐1 amidotriazoles have previously been reported to have higher selectivity for galectin‐9N (N‐terminal domain) than the corresponding galactoside C3 amidotriazoles have, which were more selective for galectin‐3.
Fredrik Sjövall, Ulf J. Nilsson
wiley   +1 more source