Results 121 to 130 of about 91,424 (147)

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source

Differences in clinical approaches of endodontists and general dentists when performing non‐surgical root canal treatment: A prospective cohort study from the National Dental Practice‐Based Research Network PREDICT Project

International Endodontic Journal, EarlyView.
Abstract Aim Information regarding differences between general dentists (GDs) and endodontists in their daily practices is limited. The aim of this prospective cohort clinical study was to compare the details of clinical approaches of GDs and endodontists when performing non‐surgical root canal treatments (NSRCT).
Ali Nosrat, Ellen Funkhouser, Alan S. Law, Omar Abusteit, Rahma Mungia, Donald R. Nixdorf, Ernest W. N. Lam, Gregg H. Gilbert   +7 more
wiley   +1 more source

ObMetrics: A Shiny app to assist in metabolic syndrome assessment in paediatric obesity

Pediatric Obesity, Volume 20, Issue 8, August 2025.
Summary Objective To introduce ObMetrics, a free and user‐friendly Shiny app that simplifies the calculation, data analysis, and interpretation of Metabolic Syndrome (MetS) outcomes according to multiple definitions in epidemiological studies of paediatric populations. We illustrate its usefulness using ethnically different populations in a comparative
Álvaro Torres‐Martos, Francisco Requena, Guadalupe López‐Rodríguez, Jhazmin Hernández‐Cabrera, Marcos Galván, Elizabeth Solís‐Pérez, Susana Romo‐Tello, José Luis Jasso‐Medrano, Jenny Vilchis‐Gil, Miguel Klünder‐Klünder, Gloria Martínez‐Andrade, María Elena Acosta Enríquez, Juan Carlos Aristizabal, Alberto Ramírez‐Mena, Nikos Stratakis, Mireia Bustos‐Aibar, Ángel Gil, Mercedes Gil‐Campos, Gloria Bueno, Rosaura Leis, Jesús Alcalá‐Fdez, Concepción María Aguilera, Augusto Anguita‐Ruiz   +22 more
wiley   +1 more source

Assessment of the Psychometric Properties of the Mask Usability Scale: A Measure of the Perceived Usability of N95 Respirators Among Healthcare Students and Staff

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To test the reliability and construct validity of the Mask Usability Scale in healthcare students and staff. Design A methodological study involving repeated measures. Methods The study included two batches of participants: (1) 283 university nursing students and (2) 1753 participants composed of students (61%) and clinical staff (39 ...
Lorna Kwai Ping Suen, Wai Hang Kwok, Ignatius Tak Sun Yu, Sony Nai Yeung So, Kin Cheung, Paul Hong Lee, Lily Yuen Wah Ho, Ka Yan Ko, Sukki Ho, Simon Ching Lam   +9 more
wiley   +1 more source

Registered Nurse‐Led Assessments in Australian Residential Aged Care Homes: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To understand the current evidence base regarding holistic nursing assessments performed by registered nurses in residential aged care homes in Australia, and identify the gaps in knowledge and potential areas for future research. Design A scoping review informed by JBI guidelines and the PRISMA extension for Scoping Reviews.
Laura Bocks, Catherine Viengkham, Merrick Powell, Julie Considine, Margaret Fry, Kate Curtis, Jo‐Ann Dalton, Karen Watson, Brendan McCormack, Mary K. Lam, Moira Dunsmore, Yun‐Hee Jeon, Richard I. Lindley, Ramon Z. Shaban   +13 more
wiley   +1 more source

The Diffusion of Deal Innovations in Complex Contractual Networks

Journal of Empirical Legal Studies, EarlyView.
ABSTRACT We introduce a new method for studying contractual evolution in complex markets. We situate the diffusion of a deal innovation within an advisory network and then provide methods for inferring a law firm's preference for adopting the innovation and for calculating each firm's proximity to prior adopters.
Kristina Bishop, Matthew Jennejohn, Cree Jones   +2 more
wiley   +1 more source

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Pd-catalyzed tandem C-H azidation and N-N bond formation of arylpyridines: a direct approach to pyrido[1,2-b]indazoles.

Organic Letters, 2013
A novel Pd-catalyzed nitrogenation of arylpyridines via C-H azidation has been developed. Direct C-N and N-N formations are achieved for this N-atom incorporation transformation using azides as the N-atom source.
Qing‐Zhong Zheng, Peng Feng, Yu-Feng Liang, N. Jiao   +3 more
semanticscholar   +1 more source

ВлиÑние на мотивационни фактори върху удовлетвореноÑтта от дейноÑтта при лекари

, 2011
ПN€Ð¾NƒN‡Ð²Ð°Ð½ÐµN‚о на моN‚иваN†Ð¸Ð¾Ð½Ð½Ð°N‚а NN„еN€Ð° е вNÐµ Ð?о-Ð?N€Ð¸N‚егаN‚елна облаNN‚ за изNÐ»ÐµÐ´Ð²Ð°Ð½Ðµ в ÐoонN‚еÐoNN‚а на NNSвN€ÐµÐ¼ÐµÐ½Ð½Ð¸N‚е изиNÐoваниN на мениджмNSнN‚а.
С. Цветкова, Ðÿ. ХриÑñ‚оð²ð°, Ðœ. Карчева, С.Ð. ÐÑÑинÑÑкий   +3 more
semanticscholar   +1 more source

Trap states in lead iodide perovskites.

Journal of the American Chemical Society, 2015
Recent discoveries of highly efficient solar cells based on lead iodide perovskites have led to a surge in research activity on understanding photo carrier generation in these materials, but little is known about trap states that may be detrimental to ...
Xiaoxi Wu, M. Trinh, D. Niesner, Haiming Zhu, Zachariah M. Norman, J. Owen, O. Yaffe, Bryan Kudisch, X. Zhu   +8 more
semanticscholar   +1 more source