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Results 121 to 130 of about 6,172,438 (249)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source

Распределение d(n,ω) в классах вычетов [PDF]

Проблемы анализа, 1995
В работе устанавливаются условия слабо равномерного распределения значений функции d(n,ω) с вещественным характером Дирихле ω(n) в классах вычетов по составному модулю и приводятся асимптотические формулы.
Широков Б. М.
doaj

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source

Razeyev D. N. I. Kant's teleology [PDF]

Кантовский сборник, 2011
Balanovsky, V. V.
doaj +1 more source

Ð˜Ð¡Ð¥Ð ÐÐÐÐ¢Ð Ð˜ ÐˆÐÐ’ÐÐžÐ¢Ðž Ð—Ð”Ð ÐÐ’ÐˆÐ• – Ð¡ÐžÐ¡Ð¢ÐžÐˆÐ‘Ð, ÐŸÐžÐ›Ð˜Ð¢Ð˜ÐšÐ˜ Ð˜ ÐŸÐ Ð•Ð”Ð˜Ð—Ð’Ð˜Ð¦Ð˜ [PDF]

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

, 2017
Acute appendicitis is very common acute surgical condition in childhood that requires quick and safe treatment with least possible complications.
Ð¡Ð¸Ð¼ÐµÐ¾Ð½Ð¾Ð², Ð Ð¸ÑÑ‚Ð¾
core +1 more source

Aplicaciones de Cálculo Diferencial [PDF]

, 2020
El trabajo que aquí se presenta fue escrito con el propósito de que sirva como complemento o consulta para estudiantes universitarios de los cursos de Cálculo Diferencial de los programas de licenciatura en Matemáticas e Informática, Física, Química y ...
Escobar Jiménez, Hernán Alberto
core

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source

philology
linguistics
extended supersymmetry

astrophysics
zoology
crystal structure