Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]
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4. BIOS - ПриÑтап до тврдиот диÑк
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информатика, МЕДИС -
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Comorbidity clusters and their relationship with severity and outcomes of index diseases, in a large multicentre systemic lupus erythematosus cohort. [PDF]
Rua-Figueroa I+42 more
europepmc +1 more source
ПолициÑтична бубрежна болеÑÑ‚ - приказ на пациент
Was to present disease, over a patient review of policystic kidney disease, that need hospitalization many times – because of complications that follow it (uroinfection, calculosis, anaemia, chronical kidney insufficiency, hypertension, and cistes crack ...
Поленаковиќ (Polenakovikj), Момир (Momir)+1 more
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This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Expert consensus on solutions to improve implementation of NICE type 2 diabetes guideline (NG28) by health systems in England: a Delphi panel by the INNOVATE-28 Working Group. [PDF]
Tahir W+8 more
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats. [PDF]
Alshahawy RZ+5 more
europepmc +1 more source
ХимичеÑкие компоненты Ñурепки обыкновенной
М. М. Маренич+2 more
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