Results 121 to 130 of about 5,652,486 (254)

Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]

, 2020
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openalex  

4. BIOS - ПриÑтап до тврдиот диÑк

, 2016
изваР...
информатика, МЕДИС -
core  

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Comorbidity clusters and their relationship with severity and outcomes of index diseases, in a large multicentre systemic lupus erythematosus cohort. [PDF]

Lupus Sci Med
Rua-Figueroa I, Pérez-Veiga N, Rodríguez-Almaraz E, Galindo-Izquierdo M, Erausquin C, Fernandez-Nebro A, Uriarte Itzazelaia E, Serrano-Benavente B, Calvo Alén J, Manrique-Arija S, Senabre JM, Bernal JA, Narvaez J, Tomero E, Aurrecoechea E, Ibáñez-Barceló M, Segarra VT, Sangüesa C, Freire-González M, García-Villanueva MJ, Martínez Taboada V, Arevalo M, Morales CM, Iñiguez C, Perez A, Salgado E, Carrión-Barberà I, Andreu JL, Cobo T, Horcada L, Bonilla G, Lozano-Rivas N, Exposito L, Montilla C, Toyos FJ, Ibarguengoitia-Barrena O, Valls Pascual E, Nóvoa Medina J, Menor-Almagro R, Roman Ivorra JA, Muñoz Jiménez A, Nolla JM, Pego-Reigosa JM.   +42 more
europepmc   +1 more source

ПолициÑтична бубрежна болеÑÑ‚ - приказ на пациент

, 2016
Was to present disease, over a patient review of policystic kidney disease, that need hospitalization many times – because of complications that follow it (uroinfection, calculosis, anaemia, chronical kidney insufficiency, hypertension, and cistes crack ...
Поленаковиќ (Polenakovikj), Момир (Momir), Миленковиќ (Milenkovikj), Звонко (Zvonko)   +1 more
core  

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Expert consensus on solutions to improve implementation of NICE type 2 diabetes guideline (NG28) by health systems in England: a Delphi panel by the INNOVATE-28 Working Group. [PDF]

BMJ Open
Tahir W, Beba H, Fortes-Mayer G, Kar P, Khan N, Milne N, Moore J, Saha S, Atkin M.   +8 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats. [PDF]

Sci Rep
Alshahawy RZ, Safwat SM, El-Kholy SS, El-Basiony SF, El-Desouky S, Helmi SM.   +5 more
europepmc   +1 more source

ХимичеÑкие компоненты Ñурепки обыкновенной

, 2012
М. М. Маренич, S. Rakhmadiyeva, Ye. Aibuldinov   +2 more
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