Results 161 to 170 of about 6,329,626 (249)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

4. BIOS - ПриÑтап до тврдиот диÑк

, 2016
изваР...
информатика, МЕДИС -
core  

Multimodal integration of coagulation biomarkers and 3D Doppler ultrasound for diagnosis of placenta accreta spectrum in pernicious placenta previa: A prospective cohort study. [PDF]

Medicine (Baltimore)
Gao M, Yang Y, Fu L, Peng Y, Liang Y, Liu Y.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ПолициÑтична бубрежна болеÑÑ‚ - приказ на пациент

, 2016
Was to present disease, over a patient review of policystic kidney disease, that need hospitalization many times – because of complications that follow it (uroinfection, calculosis, anaemia, chronical kidney insufficiency, hypertension, and cistes crack ...
Поленаковиќ (Polenakovikj), Момир (Momir), Миленковиќ (Milenkovikj), Звонко (Zvonko)   +1 more
core  

Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry. [PDF]

Eur Heart J
Lund LH, Maggioni AP, Crespo-Leiro MG, Laroche C, Gotsman I, Pojskic B, Vataman EB, Grigorica L, Sisakian H, Glavas D, Brito DA, Anker S, Chioncel O, Filippatos G, Lainscak M, McDonagh TA, Mebazaa A, Piepoli M, Ruschitzka F, Savarese G, Seferović PM, Metra M, Rosano G, ESC EORP HF III National Leaders and Investigators .   +23 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Паралелни иÑпитувања на еÑтрадиолот, прогеÑтеронот, ФСХ и ЛХ за време на менÑтруалниот циклуÑ

, 2017
The levels of estradiol, progesterone and gonadotropins were determined by radioimmunoassay in 8 healthy women, aging 18-22 years, with histories of regular menstruation.
ЧевреÑка (Chevreska), Стевка (Stevka), ДеловÑка (Delovska), ВеÑна (Vesna)   +1 more
core  

Context-Dependent Control: PKA Regulation of Vascular Ca_V1.2 Requires S1928 not Rad Phosphorylation. [PDF]

Arterioscler Thromb Vasc Biol
Voorhees HM, Taylor JL, Westhoff M, Hell JW, Dixon RE, Nieves-Cintrón M, Martín-Aragón Baudel M, Navedo MF.   +7 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source