Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu+9 more
wiley +1 more source
The efficacy of calcium and vitamin D3 supplementation in improving pregnancy and neonatal outcomes. [PDF]
Wang F+5 more
europepmc +1 more source
Characterization of ribosome heterogeneity during endothelial to hematopoietic transition
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian+4 more
wiley +1 more source
Identifying lifelong factors that impact brain health and functional outcomes in adults with childhood-onset type 1 diabetes: the cognition and longitudinal assessments of risk factors over 30 years (CLARiFY) - diabetes complications study protocol. [PDF]
Brown A+11 more
europepmc +1 more source
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source
Vitamin D Levels and Prevalence of Vitamin D Deficiency in Turkish Women According to Regions and Age Groups. [PDF]
Semiz A+5 more
europepmc +1 more source
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper+5 more
wiley +1 more source
Effect of vitamin D supplementation on glycemic control, insulin sensitivity, and pregnancy outcomes in gestational diabetes patients undergoing dietary therapy. [PDF]
Yu S, Yu X, Li F.
europepmc +1 more source
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard+3 more
wiley +1 more source