Results 51 to 60 of about 8,822,247 (206)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Depression, anxiety, and stress across the perinatal period: longitudinal trends and associations with adverse outcomes

BMC Pregnancy and Childbirth
Background Depression, anxiety, and stress are common during the perinatal period and may adversely affect maternal and neonatal outcomes. However, longitudinal data on their trajectories across pregnancy and the postpartum period, as well as their ...
Marija Žonjić, Vesna Mandić-Marković, Zorana Pavlović, Jelena Rakočević, Milica Mandić, Olivera Džatić Smiljković, Dragana Maglić, Jelena Mitrović, Nataša Maksimović, Aleksandra Nikolić   +9 more
doaj   +1 more source

To $${d}$$ d , or not to $${d}$$ d : recent developments and comparisons of regularization schemes

European Physical Journal C: Particles and Fields, 2017
We give an introduction to several regularization schemes that deal with ultraviolet and infrared singularities appearing in higher-order computations in quantum field theories.
C. Gnendiger, A. Signer, D. Stöckinger, A. Broggio, A. L. Cherchiglia, F. Driencourt-Mangin, A. R. Fazio, B. Hiller, P. Mastrolia, T. Peraro, R. Pittau, G. M. Pruna, G. Rodrigo, M. Sampaio, G. Sborlini, W. J. Torres Bobadilla, F. Tramontano, Y. Ulrich, A. Visconti   +18 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Adiponectin and Leptin—Considerations in Adult Patients with Spinal Muscular Atrophy Type 3

Diagnostics
Background: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of alpha motor neurons in the spinal cord, leading to progressive proximal muscle weakness and paralysis.
Marija Miletić, Zorica Stević, Stojan Perić, Milina Tančić Gajić, Jelena Rakočević, Miloš Stojanović, Bojan Marković, Miloš Žarković   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Roles of $$\bar{D}^{*}K^{*}$$ D ¯ ∗ K ∗ and $$D^{*}\bar{D}$$ D ∗ D ¯ molecular states in decay $$B^+ \rightarrow D^{*+} D^{-} K^{+}$$ B + → D ∗ + D - K +

European Physical Journal C: Particles and Fields
This study investigates the three-body decay process $$B^{+} \rightarrow D^{*+} D^{-} K^{+}$$ B + → D ∗ + D - K + , aiming to explore the possible origins of $$T^{*}_{\bar{c}\bar{s}0}(2870)^0$$ T c ¯ s ¯ 0 ∗ ( 2870 ) 0 and $$\chi _{c1}(3872)$$ χ c 1 ...
Zuo-Ming Ding, Qi Huang, Jun He
doaj   +1 more source