FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
ЛабораториÑки Ñтекнати инфекции кај вработените во микробиолошките лаборатории во Република Македонија [PDF]
Laboratory acquired infections (LAI) are all infections obtained during laboratory work, divided into several types, according to the manner of occurrence.
Kakaraskoska Boceska (КакараÑкоÑка БоцеÑка), Biljana (Биљана)
core +1 more source
Pull-Out Test and the Effects оf Using Different Types оf Cements and Upgrading Systems оn Endodontic Treated Teeth [PDF]
ОСÐОВÐ: Секоја дентална надградба за да ги задоволи оÑновните протетички принципи, треба да овозможи долготрајна и Ñигурна ретенција Ñо ÐºÐ¾Ñ ...
Jovanovski, Sasho+2 more
core +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
High-risk newborns and pervasive developmental disorders [PDF]
Aim of the paper: Analysis of developmental abilities in high-risk infants, with an emphasis on risk, early screening and early diagnosis of disorders of the autistic spectrum (ASD).
Dukovska, Valentina+3 more
core +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Purification tags markedly affect self‐aggregation of CPEB3
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito+6 more
wiley +1 more source
Epilepsy - Treatment with Ðcupuncture: Case Ð eport [PDF]
ЦЕЛ: Целта на овој труд е да Ñе прикаже Ñлучај Ñо епилепÑија, ÑоÑтојбата пред и поÑле третманот Ñо акупунктура и ефектите на акупунктурниот трет
ÐÑ€ÑовÑка (Arsovska), Благица (Blagica)+2 more
core +2 more sources
Загадочное зырянское слово абутор ’медведь-самец в пору течки’ [A Mysterious Komi Zyrian Word: абутор ’male bear in heat’] [PDF]
The paper investigates the Russian dialectal word абÑÑÐ¾Ñ âmale bear in heatâ and its later fixation абÑÑоÑÑ âwalking (not hibernating) bearâ. The author proposes to discuss its new interpretation.
Galina Fedyuneva
doaj +1 more source