Results 71 to 80 of about 5,652,413 (207)

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

ÐŸÐµÑ€Ñ Ð¿ÐµÐºÑ‚Ð¸Ð²Ð¸ и проблеми на обучението по приложна етика в Ð£Ð½Ð¸Ð²ÐµÑ€Ñ Ð¸Ñ‚ÐµÑ‚Ð° за национално и Ñ Ð²ÐµÑ‚Ð¾Ð²Ð½Ð¾ Ñ Ñ‚Ð¾Ð¿Ð°Ð½Ñ Ñ‚Ð²Ð¾ [PDF]

, 2020
ВаРÐμÐ ⁄ Ñ‚Ð ̧Ð ⁄ а ДраР⁄ аРР̧ÐμРа
openalex  

Effects of Antiepileptic Drugs, Carbamazepine and Phenytoin, on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in Japanese Patients With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
Ikawa K, Imura T, Nakamura S, Murata K, Morikawa N, Sakata M, Yasuzawa H, Horikawa N.   +7 more
europepmc   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2) CreERT2. [PDF]

Genesis
Amato E, Semon AM, Forni PE.
europepmc   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]

, 2020
Ð Ð ⁄ Ñ‚Ð ⁄ Ð ⁄ ГÐμруР⁄ Ð ⁄ Ð
openalex  

A novel mouse model for studying complications related to type 2 diabetes using a medium-fat diet, fructose, and streptozotocin. [PDF]

Sci Rep
Mazzocco YL, Bergero G, Del Rosso S, Cejas Gallardo ZM, Canalis AM, Baigorri RE, Mezzano L, Mladin JJ, Díaz-Gerevini GT, Martínez Benavidez C, Cano RC, Aoki MP.   +11 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Comorbidity clusters and their relationship with severity and outcomes of index diseases, in a large multicentre systemic lupus erythematosus cohort. [PDF]

Lupus Sci Med
Rua-Figueroa I, Pérez-Veiga N, Rodríguez-Almaraz E, Galindo-Izquierdo M, Erausquin C, Fernandez-Nebro A, Uriarte Itzazelaia E, Serrano-Benavente B, Calvo Alén J, Manrique-Arija S, Senabre JM, Bernal JA, Narvaez J, Tomero E, Aurrecoechea E, Ibáñez-Barceló M, Segarra VT, Sangüesa C, Freire-González M, García-Villanueva MJ, Martínez Taboada V, Arevalo M, Morales CM, Iñiguez C, Perez A, Salgado E, Carrión-Barberà I, Andreu JL, Cobo T, Horcada L, Bonilla G, Lozano-Rivas N, Exposito L, Montilla C, Toyos FJ, Ibarguengoitia-Barrena O, Valls Pascual E, Nóvoa Medina J, Menor-Almagro R, Roman Ivorra JA, Muñoz Jiménez A, Nolla JM, Pego-Reigosa JM.   +42 more
europepmc   +1 more source