ð°ñð´ð¸ñ - Open Access .click

Results 91 to 100 of about 5,541,240 (260)

, 2020
Katerina Nikoloska +3 more
openalex +2 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source

Ð•Ð¤Ð•ÐšÐ¢Ð˜ ÐÐ CYP3A4 Ð“Ð•ÐÐ•Ð¢Ð¡ÐšÐ˜ ÐŸÐžÐ›Ð˜ÐœÐžÐ Ð¤Ð˜Ð—ÐÐœ Ð’Ð Ð— ÐŸÐžÐ¡Ð¢ÐžÐŸÐ•Ð ÐÐ¢Ð˜Ð’ÐÐÐ¢Ð ÐŸÐžÐ¢Ð ÐžÐ¨Ð£Ð’ÐÐ§ÐšÐ ÐÐ Ð¤Ð•ÐÐ¢ÐÐÐ˜Ð› ÐŸÐ Ð˜ Ð¢Ð Ð•Ð¢ÐœÐÐ ÐÐ ÐŸÐžÐ¡Ð¢ÐžÐŸÐ•Ð ÐÐ¢Ð˜Ð’ÐÐÐ¢Ð Ð‘ÐžÐ›ÐšÐ [PDF]

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source

, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Ð¢Ð¾Ð·Ð¸Ñ˜Ð° (Tozija), Ð¤Ð¸Ð¼ÐºÐ° (Fimka)
core +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source

, 2006
Pavel P. Shcherbinin
openalex +1 more source

computer science
chemistry
mathematics

medicine
environmental chemistry
environmental science

combinatorics
internal medicine
political science