Results 101 to 110 of about 5,541,240 (260)

Тенденции в Ð¿Ñ€Ð¾Ð¸Ð·Ð²Ð¾Ð´Ð¸Ñ‚ÐµÐ»Ð½Ð¾Ñ Ñ‚Ñ‚Ð° на труда в Ð±ÑŠÐ»Ð³Ð°Ñ€Ñ ÐºÐ°Ñ‚Ð° минна Ð¸Ð½Ð´ÑƒÑ Ñ‚Ñ€Ð¸Ñ [PDF]

, 2020
Ð’Ðμñ Ðμð Ð ̧Ð ⁄ Ðœð ̧Ñ‚Ðμð
openalex  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Зачем программирование грамотному человеку? (Ñ Ñ Ñ Ðµ)

, 2012
Ivan Travkin
openalex   +4 more sources

Ð¡ÑŠÑ‰Ð½Ð¾Ñ Ñ‚ и Ð¿Ñ€Ð°ÐºÑ‚Ð¸Ñ‡ÐµÑ ÐºÐ¸ Ð¸Ð·Ð¼ÐµÑ€ÐµÐ½Ð¸Ñ Ð½Ð° Ð»Ð¸Ð´ÐµÑ€Ñ Ñ‚Ð²Ð¾Ñ‚Ð¾ в Ð¼ÐµÐ¶Ð´ÑƒÐ½Ð°Ñ€Ð¾Ð´Ð½Ð¸Ñ Ð¼ÐµÐ½Ð¸Ð´Ð¶Ð¼ÑŠÐ½Ñ‚ [PDF]

, 2020
СР̧Ð ⁄ ÐμÐ ⁄ Ð ⁄ СР̧Ð ⁄ ÐμÐ ⁄ Ð ⁄ Ð ⁄ Ð
openalex  

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Ðндроид/нозе и нозе/труп индекÑи одредени Ñо абÑорпциметрија Ñо двојно-енергетÑки x-зраци кај Кушинг и не-Кушинг здебелени жени [PDF]

, 2018
The aim of this study was to evaluate the central obesity, which is a main characteristic of Cushing's syndrome (CS), with dual-energy x-ray absorptiometry (DXA) and to determine DXA indexes that precisely differentiate CS from non CS obese women.
ТодоровÑка (Todorovska), Лидија (Lidija), ШубеÑка-Стратрова (Shubeska Stratrova), Славица (Slavica)   +1 more
core   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source