Results 121 to 130 of about 5,873,759 (302)

БезбедноÑта во Ñообраќајот на патиштата – предизвици за јавноздравÑтвен одговор [PDF]

open access: yes, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Тозија (Tozija), Фимка (Fimka)
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Razeyev D. N. I. Kant's teleology [PDF]

open access: yesКантовский сборник, 2011
Balanovsky, V. V.
doaj   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

N $$ \mathcal{N} $$ = (4, 4) supersymmetric AdS3 solutions in d = 11

open access: yesJournal of High Energy Physics
We derive necessary and sufficient conditions for AdS3 solutions of d = 11 supergravity to preserve N $$ \mathcal{N} $$ = (1, 1) supersymmetry in terms of G-structures.
Andrea Conti, Niall T. Macpherson
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Systematics and Faunistics of Neotropical Grapholitini, 1: Dichrorampha Guenée, 1845 (Lepidoptera: Tortricidae)

open access: yesSHILAP, 2012
Se describen dieciocho especies de Dichrorampha neotropicales (D. obliqua Razowski & Becker, sp. n., D. brusquaea Razowski & Becker, sp. n., D. mnesisocia Razowski & Becker, sp. n., D. atomosa Razowski & Becker, sp. n., D. limae Razowski & Becker, sp. n.,
J. Razowski, V. O. Becker
doaj  

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