Results 131 to 140 of about 5,541,240 (260)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Kidney Delayed Graft Function in Simultaneous Pancreas-Kidney Transplant Recipients Is Associated With Inferior Outcomes. [PDF]

Transplant Direct
Firmino SN, Fedorova E, Alshaikh EA, Kaufman D, Odorico J, Mandelbrot D, Astor BC, Parajuli S.   +7 more
europepmc   +1 more source

ХимичеÑкие компоненты Ñурепки обыкновенной

, 2012
М. М. Маренич, S. Rakhmadiyeva, Ye. Aibuldinov   +2 more
openalex  

Feedback between US and UK Prices: a Frequency Domain Analysis [PDF]

This paper decomposes the feedback between US and UK price levels by frequency over the period 1791 to 1990. By adapting Geweke's (1982) method of decomposing the feedback between time series to the case of I(1) time series generated by a bivariate error-
Jahyeong Koo, Paul A. Johnson
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Thiamine hydrochloride (VB₁) in aqueous media catalyzed the synthesis of polysubstituted quinolines <i>via</i> a one-pot strategy: a combined experimental and theoretical investigation. [PDF]

RSC Adv
Hajipour M, Mehrabi H, Masoodi HR.
europepmc   +1 more source

Ðлергии на храна врз оÑнова на ÑерумÑки Ñпецифичен ИгЕ во Република Македонија

, 2015
Slavica Hristomanova, Дејан Трајков, Александар Петличковски, Оливија Ефинска-Младеновска, Мирко Спироски   +4 more
openalex  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Vitamin D enhances the therapeutic effect of TNF-α antibodies through lipid metabolism in overweight IBD patients. [PDF]

Cell Mol Life Sci
Yu W, Huang P, Jin Y, Wu F, Zhang C, Jing L, Chen Y, Xu H, Xiong J, Zhang R, Zhao K, Li X.   +11 more
europepmc   +1 more source

Улогата на медицинÑката ÑеÑтра во MакедонÑката банка за хумана ДÐК

, 2015
Elena Cvetkovska, Мирко Спироски   +1 more
openalex