Results 31 to 40 of about 5,541,240 (260)

Clostridium difficile Strains Associated with Nosocomial Infections - Laboratory Diagnosis, Prevalence, Susceptibility and Molecular Characterization of the Isolates [PDF]

open access: yes, 2015
Иако во минатото не и Ñе придаваше големо значење на оваа бактерија, Ð´ÐµÐ½ÐµÑ Clostridium difficile е еден од најзначајните агенÑи кои Ñе поврзуваат Ñо Ð¸Ð½Ñ ...
Mihajlov, Kiril, Trajkovska Dokic, Elena
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

The DIA program ensured the growth of lending to priority sectors of the economy - by 64.5% [PDF]

open access: yes, 2018
Original title in Russian is ПроÐóрамма ÐСВ обеÑпечила роÑÑ‚ ÐºÑ€ÐµÐ´Ð¸Ñ‚Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ñ€Ð¸Ð¾Ñ€Ð¸Ñ‚ÐµÑ‚Ð½Ñ‹Ñ… отраÑлей Ñкономики – на 64 ...
Vilenovich, Perchyan Andrey
core  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Kлинички тек и иÑход кај пациенти Ñо рано дијагноÑтицирани конгенитални малформации на бубрезите и уринарниот тракт [PDF]

open access: yes, 2018
Congenital anomalies of the kidney and urinary tract- CAKUT are common childhood pathology accounting for 20-30% of all perinatally detected congenital anomalies. The importance of CAKUT is the risk they represent to kidney function deterioration and end-
ТаÑиќ (Tasic), Велибор (Velibor)   +6 more
core   +1 more source

Screening for Diabetes Type 2 in Primary Health Care [PDF]

open access: yes, 2015
Вовед. Инцидената на Ð´Ð¸Ñ˜Ð°Ð±ÐµÑ‚ÐµÑ Ñ‚Ð¸Ð¿ 2 е во пораÑÑ‚. Во делот на раното откривање потребно е да Ñе најде интервенција која најдобро ќе ја препоР...
Iliev, Darko   +2 more
core   +2 more sources

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