Results 51 to 60 of about 124 (124)

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

ÐмÑни мÑнеÑалÑÐ½Ð¾Ñ ÑÑлÑноÑÑÑ ÐºÑÑÑÐºÐ¾Ð²Ð¾Ñ Ñканини в ÑÐ¼Ð¾Ð²Ð°Ñ Ð¿Ð¾ÑÐ´Ð½Ð°Ð½Ð¾Ñ ÑÑавми нижнÑÐ¾Ñ Ñелепи Ñа ÑÑÐµÐ³Ð½Ð¾Ð²Ð¾Ñ ÐºÑÑÑки на ÑÐ»Ñ Ð³ÑпокÑнеÑиÑного оÑÑеопоÑозÑ

, 2014
Г. В. Федірко, Х. В. Погорецька, Л. О. Пацкань   +2 more
openalex   +2 more sources

ТÑомболÑÑиÑна ÑеÑапÑÑ Ð¿Ñи гоÑÑÑÐ¾Ð¼Ñ ÑÑÐ¾Ð¼Ð±Ð¾Ð·Ñ Ð³Ð»Ð¸Ð±Ð¾ÐºÐ¸Ñ Ð²ÐµÐ½ нижнÑÑ ÐºÑнÑÑвок

, 2015
М. М. Волошин
openalex   +2 more sources

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Molecular Evolution of the VP1 Gene in Human Norovirus GII.4 Variants in 1974-2015. [PDF]

Front Microbiol, 2017
Motoya T, Nagasawa K, Matsushima Y, Nagata N, Ryo A, Sekizuka T, Yamashita A, Kuroda M, Morita Y, Suzuki Y, Sasaki N, Katayama K, Kimura H.   +12 more
europepmc   +1 more source

Ð¥ÑÑÑÑгÑÑна ÑакÑика пÑи лÑкÑÐ²Ð°Ð½Ð½Ñ ÑвоÑÐ¸Ñ Ð½Ð° гоÑÑÑий калÑкÑлÑозний ÑолеÑиÑÑÐ¸Ñ Ð·Ñ ÑÑпÑÑнÑм ÑÑкÑовим дÑабеÑом II ÑипÑ

, 2015
М. В. Ріюрик
openalex   +2 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria. [PDF]

BMC Genomics, 2014
Wozniak M, Tiuryn J, Wong L.
europepmc   +1 more source