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D. Seifried, N. Stark: Energiedienstleistungen

Technikfolgenabschätzung – Theorie und Praxis, 1994
TATuP editorial office
doaj +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source

, 2016
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Ð“Ñ€Ð½Ð°Ñ€Ð¾Ð², ÐÐºÑÐµÐ½Ñ‚Ð¸
core

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source

Ð•Ð¤Ð•ÐšÐ¢Ð˜ ÐÐ CYP3A4 Ð“Ð•ÐÐ•Ð¢Ð¡ÐšÐ˜ ÐŸÐžÐ›Ð˜ÐœÐžÐ Ð¤Ð˜Ð—ÐÐœ Ð’Ð Ð— ÐŸÐžÐ¡Ð¢ÐžÐŸÐ•Ð ÐÐ¢Ð˜Ð’ÐÐÐ¢Ð ÐŸÐžÐ¢Ð ÐžÐ¨Ð£Ð’ÐÐ§ÐšÐ ÐÐ Ð¤Ð•ÐÐ¢ÐÐÐ˜Ð› ÐŸÐ Ð˜ Ð¢Ð Ð•Ð¢ÐœÐÐ ÐÐ ÐŸÐžÐ¡Ð¢ÐžÐŸÐ•Ð ÐÐ¢Ð˜Ð’ÐÐÐ¢Ð Ð‘ÐžÐ›ÐšÐ

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source

, 2018
Non-communicable diseases, also known as modern-life diseases, are the leading cause of morbidity and mortality in the world and in the Republic of Macedonia. The complexity of their occurrence, often associated with multifactorial etiology and lifestyle
ÐŸÐµÑ†ÐµÐ² (Pecev), ÐŸÐµÑ‚Ð°Ñ€ (Petar) +3 more
core

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source

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