Results 91 to 100 of about 107 (106)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto +16 more
wiley +1 more source
What Linked Data Can Tell Us About the Increasing Numbers of Children Entering Public Care
Child &Family Social Work, EarlyView.ABSTRACT The number of children in public care in Wales, UK, rose from the mid‐1990s to 2021. It is unclear if this change was related to increases in risk factors in parents, changes in the impact of risk factors, or changing policies and practices.
Nell Warner +4 more
wiley +1 more source
Assessing the Corn Belt as an anthropogenic barrier to migrating landbirds in the United States
Conservation Biology, EarlyView.Abstract Migrating landbirds adjust their flight and stopover behaviors to efficiently cross inhospitable geographies, such as the Gulf of Mexico and the Sahara Desert. In addition to these natural barriers, birds may increasingly encounter anthropogenic barriers created by large‐scale changes in land use. One such barrier could be the Corn Belt in the
Fengyi Guo +7 more
wiley +1 more source
Insights from equitable governance assessments in conservation areas around the world
Conservation Biology, EarlyView.Abstract Global policy commitments to ensure that protected and conserved areas (PCAs) are equitably governed have increased interest in empirically assessing and analyzing social equity. Although numerous assessments have been conducted in individual PCAs, there is limited empirical insight into equity as a multidimensional concept beyond the site ...
Naira Dehmel +28 more
wiley +1 more source
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications
Cell Proliferation, EarlyView.Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su +5 more
wiley +1 more source
Economic Inquiry, EarlyView.Abstract In their 2022 study, ‘The Effects of Naloxone Access Laws on Opioid Abuse, Mortality, and Crime,’ Doleac and Mukherjee conclude that broadening access to a life‐saving drug—naloxone—does not reduce opioid‐related mortality as the drug simultaneously encourages riskier drug use. I show issues with their data, design, and estimation methods. For
Sergey Alexeev
wiley +1 more source
The Economic History Review, EarlyView.Abstract Sustained long‐distance trade in the early modern era necessitated institutional mechanisms capable of solving three interrelated challenges: the need to mobilize an unprecedented volume of capital and to lock it in for long periods of time, ways of mitigating the principal–agent problem across continents, and methods to internalize and ...
Juan José Rivas Moreno
wiley +1 more source
A century of art dealing in New York. The rise of American art
The Economic History Review, EarlyView.Abstract We study art trade in New York between 1870 and 1970, analysing returns on investment by the renowned Knoedler gallery to shed light on the evolution of the American art market. A generalist art gallery should allocate investments to equalize expected returns, with differences in effective returns depending on purchase prices, number of traded
Federico Etro, Elena Stepanova
wiley +1 more source
Epilepsia, EarlyView.Abstract Objectives Responsiveness to vagus nerve stimulation (VNS) in children with drug‐resistant epilepsy (DRE) is often defined based on reduction in seizure frequency, typically at the 50% threshold, with limited consideration to the effects of therapy on seizure severity and health‐related quality of life (HRQoL). In the current report, we sought
Farbod Niazi +38 more
wiley +1 more source
Honouring the Past, Embracing the Future
The Ecumenical Review, EarlyView.Abstract The United Church of Canada, founded in 1925, represents an ambitious experiment in church union that blends Methodist, Presbyterian, and Congregationalist traditions. Over the past century, the church has played a pivotal role in shaping Canadian society by advocating for social justice, Indigenous reconciliation, interreligious dialogue ...
Hyuk Cho
wiley +1 more source