Results 21 to 26 of about 195 (26)

Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo, Fabio Arturo Iannotti, Denise Drongitis, Katiuscia Martinello, Loredana Poeta, Adriano Barra, Gaetano Terrone, Sergio Fucile, Vincenzo Di Marzo, Maria Giuseppina Miano   +9 more
wiley   +1 more source

CLE19 suppresses brassinosteroid signaling output via the BSL‐BIN2 module to maintain BES1 activity and pollen exine patterning in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
Antagonistic crosstalk between the microspore‐derived CLE19 peptide and brassinosteroid signaling preserves pollen developmental homeostasis in Arabidopsis. CLE19 activates a protein phosphatase—kinase cascade to phosphorylate the transcription factor BES1, triggering its inactivation and suppressing brassinosteroid signaling outputs, thereby fine ...
Shuangshuang Wang, Shiting Zhang, Ying Yu, Jianzheng Wang, Jingya Wang, Mengyu Li, Jianan Lu, Juanying Ye, Hanji Li, Yeqiao Liu, Yuhan Zhao, Wen Song, Juan Dong, Jia Li, Chunming Liu, Hong Ma, Fang Chang   +16 more
wiley   +1 more source

Biobased Poly(dodecylene Furanoate) with Inherent Advantages in Performance and Circularity

ChemSusChem, Volume 18, Issue 17, September 1, 2025.
Thanks to its inherent biomass furan motif that can promote polymer H‐bonding networks, biobased polyester PDDF is shown to exhibit advantages not only in performance (e.g., superior modulus, crystallinity, gas barrier properties) but also in end‐of‐life management (biodegradability and closed‐loop chemical circularity), as compared to petroleum‐based ...
Hesham Aboukeila, Eswara Rao Chokkapu, Hang‐Fei Tu, Onkar Singh, Wilfred T. Diment, Shu Xu, Meltem Urgun‐Demirtas, John Klier, George W. Huber, Brian P. Grady, Eugene Y.‐X. Chen   +10 more
wiley   +1 more source

Bayesian Network‐Based Uncertainty Quantification of Ship Isolation System Using Multi‐Level Data

Engineering Reports, Volume 7, Issue 9, September 2025.
The isolation system is divided into a multi‐level problem comprising three levels. Next, a multi‐level Bayesian network is employed to calibrate data from the first and second level. Finally, global sensitivity analysis is used to assign physical correlation weights between each level and the system level.
Rongqiao Wang, Hua Yuan, Xi Liu, Jianyuan He, Huanhuan Chen, Zhonghui Qiu, Gaoxiang Chen, Dianyin Hu   +7 more
wiley   +1 more source

Disclosure to competitors in light of endogenous firm investments

Contemporary Accounting Research, Volume 42, Issue 3, Page 1960-1986, Fall 2025.
Abstract This paper extends a familiar model of competition and disclosure to incorporate the practical feature that firms may not only hold private information about consumer demand, but they can also influence demand by the investments they make in improving product quality.
Anil Arya, Hans Frimor, Brian Mittendorf, Thomas Pfeiffer   +3 more
wiley   +1 more source

Foreign Affiliates' Position in Global Value Chains and Local Sourcing in Chile: Evidence From Plant‐Level Panel Data

The World Economy, Volume 48, Issue 9, Page 2082-2113, September 2025.
ABSTRACT Local sourcing of intermediate inputs by foreign affiliates is a major source of the positive spillover effects of foreign direct investments (FDIs) in emerging countries. However, few studies have analysed the determinants of local sourcing; studies using panel data in a specific emerging country are particularly rare.
Yoshimichi Murakami
wiley   +1 more source