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Results 131 to 140 of about 8,671,567 (248)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source

On Extended d-D Kappa Distribution

Axioms
The thermal Doppler broadening of spectral profiles for particle populations in the absence or presence of potential fields can be described by kappa distributions.
Arak M. Mathai, Hans J. Haubold
doaj +1 more source

, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Ð¢Ð¾Ð·Ð¸Ñ˜Ð° (Tozija), Ð¤Ð¸Ð¼ÐºÐ° (Fimka)
core +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source

Non- $$D{\bar{D}}$$ D D ¯ decays into light meson pairs of the D-wave charmonium $$\psi _3(3842)$$ ψ 3 ( 3842 )

European Physical Journal C: Particles and Fields
As a D-wave partner of $$\psi (3770)$$ ψ ( 3770 ) identified by the LHCb Collaboration, $$\psi _3(3842)$$ ψ 3 ( 3842 ) lies between the $$D{\bar{D}}$$ D D ¯ and $$D\bar{D^*}$$ D D ∗ ¯ thresholds.
Zi-Yue Bai, Bao-Jun Lai, Qin-Song Zhou, Xiang Liu +3 more
doaj +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda +2 more
wiley +1 more source

South Dakota Diversity of Temperature: Pictures from Statistical Analysis [PDF]

, 2007
The regional diversity of monthly temperature was analyzed based on long-term data obtained for South Dakota (SD) from the High Plains Regional Climate Center.
Boris Shmagin, Dennis Todey
core +1 more source

astrophysics
hadron-hadron scattering experiments
b physics