Results 181 to 190 of about 8,492,114 (295)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Enhancing π-Delocalization and Suppressing Traps via Doping in Electron Transport Materials for Efficient Semitransparent Organic Photovoltaics. [PDF]

Nanomicro Lett
Mo Y, Wang J, Chen H, Gong Y, Zhou J, Lu J, Yan C, Meng L, Feng LW, Li Y, Cheng P.   +10 more
europepmc   +1 more source

ÐÐÐÐÐÐÐÐЯ ÐÐÐ/ТÐ-ÐÐФÐÐÐÐÐÐÐÐ¥ Ð¥ÐÐРÐÐ¥ ÐÐ ÐÐСÐÐÐÐÐТÐÐÐÐÐ ÐÐТÐРÐТРÐÐÐРУСÐÐРТÐРÐÐÐÐ

, 2013
Д.Г. Живиця, М.А. Андрейчин   +1 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

ÐÐУÐÐÐРУÐÐÐÐÐЬÐÐÐÐЯ ÐÐÐÐÐРÐÐÐÐÐ¥ ÐÐРРÐÐРÐÐÐÐÐÐРРÐÐУÐЮÐÐÐÐЯ У ФÐРÐÐЦÐÐТÐЧÐÐÐУ ÐÐÐÐÐÐÐÐÐСТÐÐ ÐРÐÐÐ ÐС

, 2014
В.М. Хоменко, А.С. Немченко, І.К. Ярмола   +2 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Sex peptide targets distinct higher order processing neurons in the brain to induce the female post-mating response. [PDF]

Elife
Nallasivan MP, Singh DND, Sahir MSRS, Soller M.   +3 more
europepmc   +1 more source

ÐÐÐÐÐ ÐÐУÐÐÐÐÐУÐЯТÐРРÐУРÐÐÐÐÐÐÐТÐÐÐÐÐРРЯÐУ ÐРСТÐÐ ÐÐУÐÐÐРСÐСТÐÐРХÐÐРÐÐ¥ Ð ÐÐÐРШРÐÐÐÐÐÐСТÐÐÐÐÐÐ ÐÐСТРУÐТÐÐÐÐРТУÐÐРÐУÐЬÐÐÐÐ ÐÐÐÐÐЬ

, 2013
О.В. Пликанчук, С.В. Зайков   +1 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Length and Framing of Anti-Junk Food Ads Impact Inclinations to Consume Junk Food Among Normal Weight, Overweight, and Adults With Obesity. [PDF]

Health Promot J Austr
Hollett RC, Mills B, Godrich SL, Butt J, Trapp GSA.   +4 more
europepmc   +1 more source