ÐлекÑÑодинамика и пÑинÑÐ¸Ð¿Ñ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ
, 2017 Виктор Сергеевич Макаров
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
ÐолÑÑение ÑÑабилÑной ÑоÑÐ¼Ñ Ð¿Ð»Ð°Ð·Ð¼Ð¸Ð´Ð½Ð¾Ð¹ ÐÐРиз ÑÑамма E. COLI DH10B/R
, 2017 Анатолий Анатольевич Ельцов
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Periprosthetic Joint Infection Caused by <i>Brucella</i>: Four Case Reports and a Systematic Review of Literature. [PDF]
Arthroplast TodayWang S +7 more
europepmc +1 more source
РазÑабоÑка бизнеÑ-плана пÑедпÑиÑÑиÑ
, 2017 Анастасия Сергеевна Цыганова
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
ЦÐТÐÐÐÐÐÐÐРСТÐТУС Ð¥ÐÐÐ ÐÐ¥ ÐРХРÐÐÐЧÐÐÐ ÐÐÐÐТÐТ С ТРÐÐÐÐ ÐÐÐ ÐÐЦÐЯ
, 2013 Г.М. Гевко
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Design, synthesis and biological evaluation of donepezil-safinamide hybrids as dual AChE and MAO-B inhibitor for Alzheimer's disease treatment. [PDF]
J Enzyme Inhib Med ChemLi W +5 more
europepmc +1 more source