Results 111 to 116 of about 116 (116)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

An experimental approach to assess the combined effects of multiple stressors on a large vertebrate species

Conservation Biology, EarlyView.
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta, Catriona M. Harris, Lori H. Schwacke, Len Thomas, Jason B. Allen, Aaron A. Barleycorn, Marco Casoli, Jonathan Crossman, Laura Aichinger Dias, Laura Engleby, Erin LaBrecque, Jenny A. Litz, Katherine A. McHugh, Patrick J. O. Miller, Michael J. Moore, Theoni Photopoulou, Brian M. Quigley, Cynthia R. Smith, Brandon L. Southall, Todd R. Speakman, Ryan Takeshita, Christina N. Toms, Randall S. Wells, Eric S. Zolman, Peter L. Tyack   +24 more
wiley   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Demonstration of a High‐Resolution Passive Profiler for Characterizing the Distribution of PFAS in Groundwater: A Comparison of Methods in the Field

Groundwater Monitoring &Remediation, EarlyView.
Abstract Characterizing the concentration and mass flux spatial distributions at sites with complex hydrogeologic conditions is critical to evaluate the fate and transport of contaminants, as well as to design effective remediation programs. PFAS (per‐ and polyfluoroalkyl substances)‐contaminated sites are even more complex due to the large number of ...
W. Andrew Jackson, Morgan Eldridge, Jessica LaFond, Micaela Vavra, Graig Lavorgna, David Lippincott, Paul Hatzinger, Jennifer Guelfo, Todd Anderson   +8 more
wiley   +1 more source

Comparative efficacy and studies of mode of action of minerals from diatoms against three species of filth flies

Medical and Veterinary Entomology, EarlyView.
Mortality for diatomaceous earth was observed as early as 2 h after exposure with 50% and 90% mortality at 3.5 and 4.6 h (LT50 and LT90, respectively) for Musca domestica. The LT50 and LT90 increased when the size of the fly species increased (M. domestica to Cochliomyia macellaria to Sarcophaga bullata) and increased for all three from 50 to 70 ...
Grayson L. Cave, Kaiying Chen, Steven S. Denning, David W. Watson, R. Michael Roe   +4 more
wiley   +1 more source