Results 161 to 170 of about 6,152,007 (251)

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, 2014
Р. С. Турчин, В. П. Пюрик, Г. Б. Проць   +2 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Taserwest neɣ tafeltira deg umezgun n Ǧamal Benɛuf : Bu Tfuset akked Aneggaru ad yerr tawwurt d imedyaten.

Ussnan
Ǧamal Benɛuf d yiwet seg tgejda n umezgun n teqbaylit, ladɣa s tsuqilin d tserwestin i yexdem i tmiga n yimura igraɣlanen yettwasnen, am tmezgunin n Johann Wolfgang von Gothé akked Tawfiq Lḥakim.
Chabha Ben Matouk
doaj  

Effects of Irrigation Practices and N Addition Rates on Wheat Nutrient Accumulation and Utilization in Dryland. [PDF]

Plants (Basel)
Zhao C, Ren K, Sun Y, Xie Q, Zhang S, Yang M, Wu S, Huang M, Wu J, Li Y.   +9 more
europepmc   +1 more source

ФÑзÑоÑеÑапевÑиÑÐ½Ñ Ð¼ÐµÑоди лÑкÑÐ²Ð°Ð½Ð½Ñ Ñ Ð¿Ð°ÑодонÑологÑÑ

, 2014
С. І. Бойцанюк, М. А. Лучинський, В. В. Сопотніцька   +2 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults-Results from the Randomized Controlled D-Health Trial. [PDF]

Nutrients
Duarte Romero BL, Armstrong BK, Baxter C, English DR, Ebeling PR, Hartel G, Kimlin MG, Na R, McLeod DSA, Pham H, Ross T, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Neale RE, Waterhouse M.   +16 more
europepmc   +1 more source

Ðплив ÑиÑÑÐµÐ¼Ð½Ð¸Ñ ÑмÑÐ½Ð½Ð¸Ñ Ð¿Ð¾ÑÑÑÐµÐ½Ñ Ð½Ð° пеÑебÑг генеÑалÑзованого паÑодонÑиÑÑ Ñ ÑвоÑÐ¸Ñ Ð½Ð° ÑевмаÑоÑдний аÑÑÑиÑ

, 2015
І. П. Мазур, С. І. Сміян, І. І. Білозецький, І. І. Свистун   +3 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Effectiveness of Guided Internet-Based Cognitive Behavioral Therapy for Adult Anxiety and Depression in Routine Care: An Observational Study. [PDF]

Int J Methods Psychiatr Res
Jensen EK, Lichtenstein MB, Riper H, Mathiasen K.   +3 more
europepmc   +1 more source