Results 191 to 200 of about 6,171,417 (207)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Progressive Changes in Brain Morphology in People With Idiopathic Generalized Epilepsy. [PDF]

Neurology
Xiao F, Zhang Y, Wandschneider B, Binding LP, Giampiccolo D, Fleury M, Delazer L, Pimentel BC, Puntambekar I, Fukuma K, Caciagli L, Sander JW, Duncan JS, Zhou D, Koepp MJ.   +14 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system. [PDF]

Proc Natl Acad Sci U S A
Matsui S, Takahashi Y, Morioka S, Ozawa T, Kanayama S, Iwama H, Geng L, Umemoto K, Oguri Y, Tsuzuki S, Li Y, Hikida T, Sasaki T.   +12 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Associations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders. [PDF]

Addict Biol
Pavirani L, Seelarbokus BA, Marinelli L, Desnavailles P, Berthoz S, Fatseas M.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Telemedicine use in medical facilities for rural medical care and local governments in Japan. [PDF]

J Rural Med
Matsubara D, Teraura H, Honda Y, Iguchi S, Maeda T, Kotani K.   +5 more
europepmc   +1 more source

Effect of exercise on hormonal responses in adolescents with obesity and leptin resistance: a randomized trial. [PDF]

Sci Rep
Jeong D, Valentine RJ, Park K, Jeong H, Hong J, Kang S.   +5 more
europepmc   +1 more source